Response of gut microbiota to serum metabolome changes in intrahepatic cholestasis of pregnant patients

Figure 1 Distinct serum microbiome feature associated with intrahepatic cholestasis in pregnancy patients. A: Bray-Curtis principal analysis of metabolites shows significant differences between intrahepatic cholestasis in pregnancy and healthy controls; B: Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of metabolites identified in this study. The metabolites identified were subjected to a pathway enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes database. Only significantly enriched Kyoto Encyclopedia of Genes and Genomes functional categories (P < 0.05) are depicted according to their P-values. CTL: Control; ICP: Intrahepatic cholestasis in pregnancy; KEGG: Kyoto Encyclopedia of Genes and Genomes.