Contrast-enhanced ultrasound in association with serum biomarkers for differentiating combined hepatocellular-cholangiocarcinoma from hepatocellular carcinoma and intrahepatic cholangiocarcinoma

Table 1 Baseline characteristics of the study patients with combined hepatocellular-cholangiocarcinoma, intrahepatic cholangiocarcinoma and hepatocellular carcinoma

	CHC, n = 35	Non-CHC		P1	P2
		ICC, n = 29	HCC, n = 70
Tumor size in cm	5.6 ± 3.7	6.9 ± 3.3	5.1 ± 3.1	0.158	0.432
Age in yr	49.3 ± 9.5	55.0 ± 9.3	50.5 ± 9.2	0.018	0.555
Numbers of male	31 (88.6)	24 (82.8)	46 (76.7)	0.720
HBV (+)	30 (85.7)	21 (72.4)	62 (88.6)	0.224	0.756
HCV (+)	3 (8.6)	3 (10.3)	0 (0.0)	1.000	0.035
Liver cirrhosis	23 (65.7)	12 (41.4)	42 (60.0)	0.077	0.671
AFP, > 20 ng/mL	18 (51.4)	3 (10.3)	41 (58.6)	0.001	0.535
CA19-9, > 100 U/mL	4 (11.4)	9 (31.0)	1 (1.4)	0.066	0.041
AC	3 (8.6)	1 (3.4)	1 (1.4)	0.620	0.107

Data are numbers of lesions, with percentages in parentheses or mean ± SD. P1 statistical difference between combined hepatocellular-cholangiocarcinoma (CHC) and intrahepatic cholangiocarcinoma (ICC). P2 statistical difference between CHC and hepatocellular carcinoma (HCC). AC means simultaneous elevated alpha-fetoprotein (AFP) and carbohydrate antigen 19-9 levels (CA19-9).