Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer

Figure 4 Different genus among the three groups and linear discriminant analysis effect size analysis of fecal bacterial of colorectal cancer patients and healthy controls. A: Top 20 different genus among the three groups with a Kruskal-Wallis’s P value < 0.05; B: Cladogram showing enriched taxa in the colorectal cancer (CRC) patient and healthy control (HC) groups; the taxa represented by the English letters in the cladogram are shown in the legend on the right; C: Taxa enriched in HCs are indicated with a negative score and the taxa enriched in the CRC group are indicated with a positive linear discriminant analysis (LDA) score; only taxa with an LDA effect size’s P value < 0.05 and an LDA score ≥ 2.0 are showed. LDA: Linear discriminant analysis; HC: Healthy control; CRC: Colorectal cancer.