Liver fibrosis index-based nomograms for identifying esophageal varices in patients with chronic hepatitis B related cirrhosis

Table 3 Univariate and multivariate logistic regression analyses for esophageal varices severity in patients with chronic hepatitis B related cirrhosis in the training cohort

Variable	Univariate analysis			Multivariate analysis
	OR	95%CI	P value	OR	95%CI	P value
Clinical parameter
Age (yr)	0.997	0.967-1.027	0.833
Gender (Female = 0, Male = 1)	0.898	0.372-2.168	0.811
BMI (kg/m2)	1.011	0.904-1.132	0.844
SBP (mmHg)	1.001	0.983-1.019	0.928
DBP (mmHg)	0.992	0.962-1.022	0.584
Child-Pugh class	5.161	2.344-11.361	< 0.001	5.436	2.112-13.990	< 0.001
(Child A = 1, Child B/C = 2)
Laboratory test
TBil (µmol/L)	1.000	0.989-1.012	0.937
DBil (µmol/L)	0.996	0.980-1.012	0.643
TP (g/L)	0.978	0.942-1.015	0.246
Albumin (g/L)	0.987	0.937-1.038	0.605
ALT (IU/L)	0.994	0.986-1.001	0.109
AST (IU/L)	0.997	0.991-1.003	0.282
ALP (IU/L)	1.001	0.995-1.007	0.637
GGT (IU/L)	0.997	0.995-1.000	0.064
INR	10.764	2.342-49.469	0.002
PLT (× 109/L)	0.994	0.989-0.999	0.016
MPV (fl)	1.399	1.050-1.865	0.022	1.479	1.043-2.098	0.028
PDW (fl)	1.036	0.920-1.166	0.564
Ultrasound parameter
HAD (mm)	1.327	0.693-2.541	0.393
HAPV (cm/s)	1.025	0.995-1.057	0.108
PVD (mm)	1.465	1.126-1.906	0.004	1.397	1.021-1.912	0.037
MPVV (cm/s)	0.964	0.899-1.033	0.301
SAD (mm)	0.973	0.678-1.396	0.880
SAPV (cm/s)	1.000	0.977-1.024	0.985
SVD (mm)	1.109	0.900-1.366	0.332
MSVV (cm/s)	1.062	0.979-1.151	0.148
ST (mm)	1.146	1.077-1.218	< 0.001
SD (mm)	1.030	1.010-1.049	0.003
SPI	1.644	1.193-2.265	0.002	1.463	1.030-2.079	0.034
LFI	4.184	2.080-8.416	< 0.001	3.089	1.442-6.617	0.004

The bold P values represent P < 0.05. OR: Odds ratio; 95%CI: 95% Confidence interval; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; TBil: Total bilirubin; DBil: Direct bilirubin; TP: Total protein; ALT: Alanine transaminase; AST: Aspartic transaminase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transpeptidase; INR: International normalized ratio; PLT: Platelet count; MPV: Mean platelet volume; PDW: Platelet distribution width; HAD: Hepatic artery diameter; HAPV: Hepatic artery peak velocity; PVD: Portal vein diameter; MPVV: Mean portal vein velocity; SAD: Splenic artery diameter; SAPV: Splenic artery peak velocity; SVD: Splenic vein diameters; MSVV: Mean splenic vein velocity; ST: Spleen thick; SD: Spleen diameter; SPI: Splenic portal index; LFI: Liver fibrosis index.