Liver fibrosis index-based nomograms for identifying esophageal varices in patients with chronic hepatitis B related cirrhosis

Table 2 Univariate and multivariate logistic regression analyses for esophageal varices risk in patients with chronic hepatitis B related cirrhosis in the training cohort

Variable	Univariate analysis			Multivariate analysis
	OR	95%CI	P value	OR	95%CI	P value
Clinical parameter
Age (yr)	1.038	1.001-1.076	0.043
Gender (Female = 0, Male = 1)	0.994	0.375-2.633	0.990
BMI (kg/m2)	1.031	0.907-1.171	0.643
SBP (mmHg)	1.005	0.985-1.025	0.657
DBP (mmHg)	0.985	0.953-1.018	0.367
Child-Pugh class	7.990	2.979-21.426	< 0.001	7.705	2.169-27.370	0.002
(Child A = 1, Child B/C = 2)
Laboratory test
TBil (µmol/L)	1.001	0.988-1.013	0.930
DBil (µmol/L)	0.998	0.981-1.016	0.831
TP (g/L)	0.976	0.936-1.018	0.255
Albumin (g/L)	0.932	0.877-0.990	0.022
ALT (IU/L)	0.992	0.984-1.000	0.052
AST (IU/L)	0.997	0.990-1.003	0.294
ALP (IU/L)	1.009	0.999-1.018	0.065
GGT (IU/L)	0.998	0.995-1.000	0.081
INR	20.331	2.870-144.037	0.003
PLT (× 109/L)	0.990	0.985-0.995	< 0.001	0.992	0.984-1.000	0.044
MPV (fl)	1.373	0.999-1.887	0.051
PDW (fl)	1.128	0.981-1.297	0.092
Ultrasound parameter
HAD (mm)	1.619	0.786-3.335	0.192
HAPV (cm/s)	1.017	0.984-1.051	0.318
PVD (mm)	1.505	1.121-2.021	0.006
MPVV (cm/s)	0.915	0.845-0.991	0.029
SAD (mm)	0.935	0.629-1.390	0.740
SAPV (cm/s)	0.995	0.970-1.021	0.711
SVD (mm)	1.086	0.860-1.372	0.489
MSVV (cm/s)	1.073	0.977-1.180	0.142
ST (mm)	1.312	1.178-1.462	< 0.001
SD (mm)	1.036	1.012-1.059	0.003
SPI	4.183	2.044-8.559	< 0.001	3.895	1.630-9.308	0.002
LFI	7.067	2.938-16.995	< 0.001	3.603	1.336-9.719	0.011

The bold P values represent P < 0.05. OR: Odds ratio; 95%CI: 95% Confidence interval; BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; TBil: Total bilirubin; DBil: Direct bilirubin; TP: Total protein; ALT: Alanine transaminase; AST: Aspartic transaminase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transpeptidase; INR: International normalized ratio; PLT: Platelet count; MPV: Mean platelet volume; PDW: Platelet distribution width; HAD: Hepatic artery diameter; HAPV: Hepatic artery peak velocity; PVD: Portal vein diameter; MPVV: Mean portal vein velocity; SAD: Splenic artery diameter; SAPV: Splenic artery peak velocity; SVD: Splenic vein diameters; MSVV: Mean splenic vein velocity; ST: Spleen thick; SD: Spleen diameter; SPI: Splenic portal index; LFI: Liver fibrosis index.