Liver fibrosis index-based nomograms for identifying esophageal varices in patients with chronic hepatitis B related cirrhosis

Table 1 Patient’s clinical characteristics of the training and validation cohort

Variable	Training cohort (n = 123)	Validation cohort (n = 184)	P value
Clinical parameter
Age (yr)	54.05 ± 12.02	54.54 ± 12.25	0.727
Male (%)	96 (78.05)	147 (79.89)	0.697
BMI (kg/m2)	22.97 ± 3.24	22.91 ± 3.41	0.877
SBP (mmHg)	129.29 ± 20.62	129.03 ± 20.56	0.914
DBP (mmHg)	71.77 ± 12.16	71.41 ± 11.76	0.796
Child-Pugh class A (%)	58 (47.15)	86 (46.74)	0.943
Degree of EV (Q1, Q3)	2 (0, 3)	2 (0, 3)	0.873
0 (%)	32 (26.02)	48 (26.09)
1 (%)	16 (13.01)	26 (14.13)
2 (%)	21 (17.07)	25 (13.59)
3 (%)	54 (43.90)	85 (46.19)
Laboratory test
TBil (µmol/L)	19.00 (12.00, 31.00)	18.50 (12.00, 31.00)	0.943
DBil (µmol/L)	9.00 (5.00, 16.00)	9.00 (5.00, 17.00)	0.766
TP (g/L)	65.80 ± 10.03	66.05 ± 9.95	0.831
Albumin (g/L)	32.85 ± 7.11	33.14 ± 7.14	0.726
ALT (IU/L)	27.00 (20.00, 47.00)	27.50 (20.25, 47.00)	0.850
AST (IU/L)	38.00 (28.00, 70.00)	41.00 (28.00, 70.75)	0.734
ALP (IU/L)	94.00 (74.00, 131.00)	99.00 (73.00, 140.00)	0.728
GGT (IU/L)	51.00 (24.00, 126.00)	50.00 (29.25, 126.75)	0.865
INR	1.36 (1.17, 1.54)	1.36 (1.17, 1.54)	0.994
PLT (× 109/L)	82.00 (53.00, 140.00)	84.00 (56.00, 139.00)	0.760
MPV (fl)	11.50 (10.50, 12.50)	11.30 (10.40, 12.30)	0.301
PDW (fl)	14.90 (12.60, 17.30)	14.65 (12.70, 17.18)	0.760
Ultrasound parameter
HAD (mm)	3.46 ± 0.56	3.47 ± 0.57	0.914
HAPV (cm/s)	50.35 ± 12.23	50.51 ± 13.33	0.915
PVD (mm)	12.30 ± 1.54	12.05 ± 1.61	0.186
MPVV (cm/s)	19.11 ± 5.28	19.93 ± 5.59	0.196
SAD (mm)	5.05 ± 1.00	5.00 ± 0.98	0.678
SAPV (cm/s)	55.89 ± 15.38	55.91 ± 16.03	0.990
SVD (mm)	9.61 ± 1.82	9.59 ± 1.70	0.899
MSVV (cm/s)	22.22 ± 4.93	22.69 ± 5.20	0.428
ST (mm)	44.47 ± 9.36	44.61 ± 9.68	0.900
SD (mm)	110.88 ± 23.73	112.27 ± 25.39	0.629
SPI	2.96 ± 1.75	2.92 ± 1.96	0.871
LFI	3.74 ± 0.69	3.72 ± 0.68	0.886

BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; EV: Esophageal varices; Q1: 1^st quartile; Q3: 3^rd quartile; TBil: Total bilirubin; DBil: Direct bilirubin; TP: Total protein; ALT: Alanine transaminase; AST: Aspartic transaminase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transpeptidase; INR: International normalized ratio; PLT: Platelet count; MPV: Mean platelet volume; PDW: Platelet distribution width; HAD: Hepatic artery diameter; HAPV: Hepatic artery peak velocity; PVD: Portal vein diameter; MPVV: Mean portal vein velocity; SAD: Splenic artery diameter; SAPV: Splenic artery peak velocity; SVD: Splenic vein diameters; MSVV: Mean splenic vein velocity; ST: Spleen thick; SD: Spleen diameter; SPI: Splenic portal index; LFI: Liver fibrosis index.