High mortality associated with gram-negative bacterial bloodstream infection in liver transplant recipients undergoing immunosuppression reduction

Table 4 Univariate and multivariate Cox regression analysis of risk factors for 30 d mortality after Gram-negative bacterial infections in liver transplant recipients

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	aHR (95%CI)	P value
Age	1.025 (0.969-1.085)	0.392
Sex	0.778 (0.157-3.857)	0.759
Etiology of liver transplant
Hepatocellular carcinoma	0.839 (0.169-4.157)	0.829
Hepatitis B virus	0.666 (0.159-2.79)	0.578
Rejection1	13.89 (2.741-70.376)	0.001	7.021 (1.581-31.188)	0.01
BSI source
Primary	0.044 (0.00-3.849)	0.581
Respiratory tract	1.987 (0.448-8.81)	0.366
Intra-abdominal	1.343 (0.391-4.611)	0.639
Biliary tract	2.376 (0.72-7.843)	0.156
Urinary tract	0.51 (0.063-4.146)	0.529
Pathogen
Klebsiella pneumoniae	5.165 (1.22-21.87)	0.026		0.47
Acinetobacter baumannii	0.038 (0.00-125.635)	0.428
Management of infection
Empiric therapy	0.545 (0.13-2.282)	0.406
Target therapy	1.539 (0.384-6.163)	0.543
Source control	1.6 (0.197-13.018)	0.661
Management of immunosuppressive therapy
IS reduction	0.026 (0.0-12.782)	0.249
Complete IS withdrawal	14.362 (1.818-113.46)	0.012	12.65 (1.51-105.965)	0.019

¹Within 90 d after bloodstream infection. aHR: Adjusted hazard ratio; BSI: Bloodstream infection; CI: Confidence interval; HR: Hazard ratio; IS: Immunosuppression.