Case Control Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Dec 7, 2020; 26(45): 7173-7190
Published online Dec 7, 2020. doi: 10.3748/wjg.v26.i45.7173
Table 2 Concentrations of tryptophan and tryptophan metabolites in patients and healthy controls
Metabolite (nmol/L)Controls (n = 28)ADA patients (n = 24) CRC patients (n = 39) Intergroup comparisons (P value)
HC/ADA
HC/CRC
ADA/CRC
Trp196.67 (125.10, 353.30)289.46 (206.2, 393.72)241.88 (165.98, 429.16)0.0810.1180.611
KYN0.81 (0.64, 1.57)0.94 (0.66, 2.25)1.51 (0.70, 3.46)0.6270.0360.140
Indole252.00 (170.00, 545.00)251.00 (66.50, 366.75)356.00 (128.50, 729.25)0.2130.8780.170
Skatole210.00 (172.00, 223.00)137.00 (115.00, 206.00)231.00 (147.50, 265.50)0.1110.4950.019
IAA6.56 (1.25, 20.59)6.63 (3.35, 18.82)7.61 (1.85, 16.1)0.4010.9430.876
IPA10.67 (6.36, 15.48)7.75 (4.55, 10.38)7.65 (4.19, 13.11)0.0250.0250.348
IALD8.00 (4.25 15.50)19.50 (8.25, 31.75)37.00 (13.00, 63.00)0.04400.024
I3CA1.13 (0.81, 1.71)1.10 (0.74, 2.11)3.64 (1.79, 8.15)0.9710.0110.028
Indoles428.24 (276.45, 963.95)325.50 (179.82, 504.33)547.87 (247.97, 823.64)0.1000.9550.044
Indoles/Trp ratio2.46 (1.25, 4.10)1.48 (0.58, 1.97)1.34 (0.70, 2.63)0.0030.0290.413
KYN/Trp ratio (× 10-3)5.23 (1.86, 7.99)3.73 (1.99, 11.39)7.39 (4.12, 11.72)0.8450.0320.105