Discovery of unique African Helicobacter pylori CagA-multimerization motif in the Dominican Republic

Table 3 CagA-multimerization motif patterns in Helicobacter pylori strains

CM motif pattern	Occurrence	Frequency (%)
W-W	30	35.7
W-Af1	27	32.1
W-D	10	11.9
D-Af1	5	6.0
W-W-W	5	6.0
W-Af1-Af1	2	2.4
-W	2	2.4
D-D	1	1.2
W-E	1	1.2
W-	1	1.2
Total	84

CagA-multimerization (CM) motif patterns were determined based on the identification of CM sequences that were located before and after the (Glu-Pro-Ile-Tyr-Ala)-C motif. W-W: Strains with two Western CM motifs in their CagA; W-Af1: Strains with one Western and one Africa1 CM motif in their CagA; W-D: Strains with one Western and one Different CM motif in their CagA; D-Af1: Strains with one Different and one Africa1 CM motif in their CagA; W-W-W: Strains with three Western CM motifs in their CagA; W-Af1-Af1: Strains with one Western and two Africa1 CM motifs in their CagA; -W: Indicates that only one Western CM motif was observed following the Glu-Pro-Ile-Tyr-Ala (EPIYA)-C motif, in the absence of a CM motif before the EPIYA-C motif; D-D: Strains with two Different CM motifs in their CagA; W-E: Strains with one Western and one East Asian CM motif in their CagA; W-: Indicates that only one Western CM motif was observed before the EPIYA-C motif, in the absence of a CM motif following the EPIYA-C motif.