Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study

Table 6 Sensitivity analysis stratified by gender

Gender	Cancer	Group	HR (95%CI)
			Model 1	Model 2	Model 3
Male	Liver	Quartile 1	1.00 (reference)	1.00 (reference)	1.00 (reference)
		Quartile 2	0.88 (0.55-1.40)	0.92 (0.57-1.46)	0.86 (0.54-1.38)
		Quartile 3	0.60 (0.36-1.01)	0.62 (0.37-1.05)	0.56 (0.33-0.94)
		Quartile 4	0.99 (0.63-1.55)	0.99 (0.63-1.56)	0.81 (0.51-1.29)
	Gallbladder	Quartile 1	1.00 (reference)	1.00 (reference)	1.00 (reference)
		Quartile 2	3.04 (0.32-29.21)	3.20 (0.90-11.35)	3.01 (0.85-10.67)
		Quartile 3	4.92 (0.57-42.13)	5.22 (1.78-15.28)	4.58 (1.57-13.41)
		Quartile 4	5.52 (0.66-45.96)	5.85 (2.08-16.43)	4.64 (1.65-13.03)
	Biliary tract	Quartile 1	1.00 (reference)	1.00 (reference)	1.00 (reference)
		Quartile 2	0.83 (0.34-1.99)	0.87 (0.36-2.10)	0.88 (0.36-2.17)
		Quartile 3	0.82 (0.34-1.97)	0.88 (0.36-2.15)	0.83 (0.33-2.06)
		Quartile 4	0.70 (0.28-1.73)	0.77 (0.30-1.93)	0.64 (0.24-1.68)
	Pancreas	Quartile 1	1.00 (reference)	1.00 (reference)	1.00 (reference)
		Quartile 2	1.04 (0.70-1.55)	1.07 (0.72-1.59)	1.06 (0.71-1.59)
		Quartile 3	1.37 (0.95-1.99)	1.41 (0.97-2.04)	1.33 (0.91-1.95)
		Quartile 4	1.15 (0.78-1.69)	1.17 (0.79-1.73)	1.11 (0.74-1.66)
Female	Liver	Quartile 1	1.00 (reference)	1.00 (reference)	1.00 (reference)
		Quartile 2	0.91 (0.45-1.81)	0.92 (0.46-1.85)	0.89 (0.44-1.78)
		Quartile 3	0.98 (0.50-1.92)	1.00 (0.51-1.95)	0.92 (0.47-1.83)
		Quartile 4	1.05 (0.55-2.00)	1.02 (0.53-1.96)	0.88 (0.43-1.76)
	Gallbladder	Quartile 1	1.00 (reference)	1.00 (reference)	1.00 (reference)
		Quartile 2	2.06 (0.53-7.98)	2.13 (0.55-8.24)	2.11 (0.54-8.20)
		Quartile 3	2.38 (0.64-8.81)	2.47 (0.66-9.15)	2.42 (0.64-9.15)
		Quartile 4	2.08 (0.56-7.74)	2.10 (0.56-7.85)	2.02 (0.51-8.08)
	Biliary tract	Quartile 1	1.00 (reference)	1.00 (reference)	1.00 (reference)
		Quartile 2	1.56 (0.46-5.33)	1.56 (0.45-5.33)	1.48 (0.43-5.09)
		Quartile 3	0.80 (0.20-3.22)	0.80 (0.20-3.23)	0.72 (0.18-2.97)
		Quartile 4	1.23 (0.36-4.26)	1.29 (0.37-4.47)	1.04 (0.27-3.96)
	Pancreas	Quartile 1	1.00 (reference)	1.00 (reference)	1.00 (reference)
		Quartile 2	0.78 (0.47-1.32)	0.78 (0.46-1.31)	0.77 (0.46-1.29)
		Quartile 3	1.21 (0.77-1.92)	1.20 (0.76-1.90)	1.16 (0.73-1.85)
		Quartile 4	2.07 (1.37-3.13)	2.05 (1.35-3.10)	1.93 (1.24-3.01)

Model 1 adjusted for age, education, ethnic group and family history of cancer. Model 2 adjusted for age, education, ethnic group, family history of cancer, alcohol intake, smoking status, annual household income, fruit and vegetable intake and physical activity. Model 3 additionally adjusted for body mass index based on model 2. Participants with less than 2 yrs of follow-up were excluded. HR: Hazard ratio; CI: Confidence interval.