Role of doublecortin-like kinase 1 and leucine-rich repeat-containing G-protein-coupled receptor 5 in patients with stage II/III colorectal cancer: Cancer progression and prognosis

Table 1 Correlation of immunoreactivity of doublecortin-like kinase 1 and leucine-rich repeat-containing G-protein-coupled receptor 5 with clinicopathological features

Clinicopathologic characteristics	n (%)	DCLK1		P value	Lgr5		P value
		Low (n = 48)	High (n = 44)		Low (n = 62)	High (n = 30)
Age (yr)
≤ 49	49 (53)	26 (53)	23 (47)	0.856	33 (67)	16 (33)	0.992
> 49	43 (47)	22 (51)	21 (49)		29 (67)	14 (33)
Gender
Male	52 (57)	29 (56)	23 (44)	0.431	37 (71)	15 (29)	0.380
Female	40 (43)	19 (47)	21 (53)		25 (63)	15 (37)
Depth of penetration
T3	18 (20)	6 (33)	12 (67)	0.074	13 (72)	5 (28)	0.626
T4	74 (80)	42 (57)	32 (43)		49 (66)	25 (34)
Lymph node
N0	38 (41)	20 (53)	18 (47)	0.892	27 (71)	11 (29)	0.787
N1	41 (45)	22 (54)	19 (46)		27 (66)	14 (34)
N2	13 (14)	6 (12)	7 (16)		8 (62)	5 (38)
Tumor stage (TNM)
II	38 (41)	20 (55)	18 (45)	0.941	27 (71)	11 (29)	0.530
III	54 (59)	28 (52)	26 (48)		35 (65)	19 (35)
Differentiation
Well/moderate	66 (72)	37 (56)	29 (44)	0.234	48 (73)	18 (27)	0.082
Poor/mucinous	26 (28)	11 (42)	15 (58)		14 (54)	12 (46)
Tumor site
Left	42 (46)	24 (57)	18 (43)	0.537	32 (76)	10 (24)	0.032
Right	17 (18)	7 (41)	10 (59)		7 (41)	10 (59)
Rectum	33 (36)	17 (52)	16 (48)		23 (70)	10 (30)
Postoperative adjuvant chemotherapy
Xeloda monotherapy	7 (7)	4 (57)	3 (43)	0.783	5 (71)	2 (29)	0.763
FOLFOX regimen	32 (35)	18 (56)	14 (44)		20 (63)	12 (37)
XELOX regimen	53 (58)	26 (49)	27 (51)		37 (70)	16 (30)
CEA
Normal	68 (74)	38 (56)	30 (44)	0.231	45 (66)	23 (34)	0.676
High	24 (26)	10 (42)	14 (58)		17 (71)	7 (29)
CA19-9
Normal	66 (72)	35 (53)	31 (47)	0.793	45 (68)	21 (32)	0.797
High	26 (28)	13 (50)	13 (50)		17 (67)	9 (33)
MSI
MSS	89 (97)	46 (52)	43 (48)	0.609	60 (67)	29 (33)	0.978
MSI	3 (3)	2 (67)	1 (33)		2 (67)	1 (33)
Recurrence
Absent	67 (73)	37 (55)	30 (45)	0.338	44 (66)	23 (34)	0.565
Present	25 (27)	11 (44)	14 (56)		18 (72)	7 (28)
Lung metastasis
Absent	80 (87)	40 (50)	40 (50)	0.281	52 (65)	28 (35)	0.206
Present	12 (13)	8 (67)	4 (33)		10 (83)	2 (17)
Liver metastasis
Absent	83 (90)	42 (51)	41 (49)	0.359	55 (66)	28 (34)	0.484
Present	9 (10)	6 (67)	3 (33)		7 (78)	2 (22)

DCLK1: Doublecortin-like kinase 1; Lgr5: Leucine-rich repeat-containing G-protein-coupled receptor 5; TNM: Tumor-node-metastasis.