Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma

Figure 7 Upregulated mRNA expression of yes-associated protein-1 was correlated with the expression of activating transcription factor-6 in human hepatocellular carcinoma tissues. A: The mean mRNA expression of yes-associated protein-1 (YAP-1) was upregulated by 2.6-fold in hepatocellular carcinoma (HCC) tissues compared with nontumor tissues (n = 88). The data are expressed as the mean ± SD; B: The mRNA expression of YAP-1 was positively correlated with the mRNA expression of ATF6 (Pearson’s coefficient = 0.299; P < 0.05); C: The expression of YAP-1 in human HCC tissue was detected by immunohistochemistry (400 × magnification). Scale bars, 50 μm. YAP: Yes-associated protein; HCC: Hepatocellular carcinoma; SD: Standard deviation; ATF-6: Activating transcription factor-6; HE: Hematoxylin-eosin.