Copyright
©The Author(s) 2020.
World J Gastroenterol. Nov 7, 2020; 26(41): 6455-6474
Published online Nov 7, 2020. doi: 10.3748/wjg.v26.i41.6455
Published online Nov 7, 2020. doi: 10.3748/wjg.v26.i41.6455
Table 4 Summary of the multivariable regression analyses for health resources utilization in the included moderate to severe Crohn’s disease patients
Outcome type | Outpatient visits | Hospital admissions related to active disease | Hospital stay length related to active disease | ||||||||||||
Regression analysis method | Poisson regression analysis | Poisson regression analysis | Linear regression analysis | ||||||||||||
Independent variables | Sample size | Coefficient | 95%CI | P value | Sample size | Coefficient | 95%CI | P value | Sample size | Coefficient | 95%CI | P value | |||
Lower | Upper | Lower | Upper | Lower | Upper | ||||||||||
IMT vs CMT | 238 | -0.564 | -0.703 | -0.425 | 0.000 | 291 | -0.074 | -0.276 | 0.128 | 0.470 | 389 | -4.725 | -7.112 | -2.337 | 0.000 |
BMI | |||||||||||||||
< 18.5 | 291 | 0.244 | -0.122 | 0.643 | 0.209 | 389 | 5.510 | 1.587 | 9.433 | 0.006b | |||||
18.5-23.9 | 291 | -0.020 | -0.382 | 0.375 | 0.917 | 389 | -0.759 | -4.449 | 2.932 | 0.686 | |||||
Lifestyles | |||||||||||||||
Smoker | 238 | 0.073 | -0.231 | 0.355 | 0.623 | ||||||||||
Residence area | |||||||||||||||
Urban city | 238 | 0.693 | 0.558 | 0.830 | 0.000 | ||||||||||
Insurance plan | |||||||||||||||
Urban workers | 238 | -0.070 | -0.230 | 0.092 | 0.392 | ||||||||||
Urban residents | 238 | -0.442 | -0.696 | -0.196 | 0.001b | ||||||||||
Disease site at diagnosis | |||||||||||||||
Terminal ileum | 238 | 0.113 | -0.086 | 0.314 | 0.268 | 389 | -2.100 | -5.085 | 0.884 | 0.167 | |||||
Colon | |||||||||||||||
Ileocolon | 238 | 0.128 | -0.057 | 0.317 | 0.179 | 389 | -2.505 | -5.099 | 0.089 | 0.058 | |||||
End ileum + upper digestive tract | 291 | 0.222 | -0.359 | 0.731 | 0.421 | ||||||||||
Ileocolon + upper digestive tract | 238 | 0.502 | 0.162 | 0.825 | 0.003b | 291 | 0.253 | -0.218 | 0.670 | 0.263 | |||||
History of CD-related complications | |||||||||||||||
Pyloric obstruction | 238 | -0.247 | -1.698 | 0.815 | 0.690 | 291 | 0.819 | 0.080 | 1.450 | 0.018a | |||||
Intestinal fistula | 238 | 0.028 | -0.272 | 0.312 | 0.850 | ||||||||||
Intestinal obstruction | 238 | 0.372 | 0.183 | 0.555 | 0.000 | ||||||||||
Extraintestinal abscess | 389 | 11.363 | 4.696 | 18.030 | 0.001b | ||||||||||
Anal fistula | 291 | 0.241 | 0.007 | 0.468 | 0.040a | 389 | -0.316 | -2.710 | 2.078 | 0.795 | |||||
Perianal abscess | 291 | 0.150 | -0.091 | 0.383 | 0.214 | ||||||||||
Extraintestinal manifestations | |||||||||||||||
Joint pain | 238 | -0.438 | -0.919 | -0.013 | 0.057 | ||||||||||
Mouth ulcers | 238 | -0.465 | -0.936 | -0.053 | 0.038a | ||||||||||
History of CD-related surgery | 238 | -0.117 | -0.291 | 0.054 | 0.184 | ||||||||||
Comorbidities | |||||||||||||||
HP infection | 238 | 1.168 | 0.588 | 1.672 | 0.000 | ||||||||||
Rhinitis | 238 | 1.439 | 0.221 | 2.966 | 0.034a | ||||||||||
Gallbladder disease | 238 | -0.233 | -0.640 | 0.133 | 0.235 | ||||||||||
Tuberculosis | 389 | 6.773 | -2.555 | 16.100 | 0.154 | ||||||||||
Peritonitis | 238 | 1.986 | 1.438 | 2.471 | 0.000 | 291 | 0.872 | -0.321 | 1.759 | 0.091 | 389 | 53.048 | 32.426 | 73.671 | 0.000 |
Abdominal abscess | 238 | NA | NA | NA | NS | 291 | NA | NA | NA | NS | 389 | NA | NA | NA | NS |
fracture | 291 | 1.213 | 0.030 | 2.080 | 0.017a | ||||||||||
Osteoporosis | 238 | -0.159 | -1.626 | 0.945 | 0.802 | ||||||||||
Muscle atrophy | 389 | 45.956 | 23.426 | 68.486 | 0.000 | ||||||||||
Arrhythmia | 238 | -1.109 | -2.919 | 0.055 | 0.123 | ||||||||||
Hepatitis B virus carriers | 238 | -0.358 | -1.062 | 0.235 | 0.275 |
- Citation: Shi JH, Luo L, Chen XL, Pan YP, Zhang Z, Fang H, Chen Y, Chen WD, Cao Q. Real-world cost-effectiveness associated with infliximab maintenance therapy for moderate to severe Crohn’s disease in China. World J Gastroenterol 2020; 26(41): 6455-6474
- URL: https://www.wjgnet.com/1007-9327/full/v26/i41/6455.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i41.6455