Real-world cost-effectiveness associated with infliximab maintenance therapy for moderate to severe Crohn’s disease in China

Table 3 Summary of the multivariable regression analyses for clinical outcomes in the included moderate to severe Crohn’s disease patients

Outcome type	Disease remission					CD-related surgery					CD-related complications					Utility, quality of life
Regression analysis method	Logistic regression analysis					Logistic regression analysis					Logistic regression analysis					Beta-binomial regression analysis
Independent variables	Sample size	OR	95%CI		P value	Sample size	OR	95%CI		P value	Sample size	OR	95%CI		P value	Sample size	Coefficient	95%CI		P value
			Lower	Upper				Lower	Upper				Lower	Upper				Lower	Upper
IMT vs CMT	389	4.060	1.643	10.753	0.003a	389	0.658	0.349	1.249	0.196	389	0.527	0.323	0.858	0.010a	389	0.822	0.218	1.426	0.008a
Demographics
Male gender											389	1.111	0.675	1.844	0.681	389	-0.008	-0.622	0.607	0.980
Age in yr	389	0.951	0.918	0.986	0.005	389	1.027	1.002	1.052	0.035a	389	0.990	0.968	1.011	0.351	389	-0.016	-0.041	0.010	0.223
BMI
< 18.5						389	1.936	0.682	6.535	0.244
18.5-23.9						389	0.826	0.292	2.755	0.733
Residence area
Urban city						389	0.521	0.246	1.035	0.073
Insurance plan
Farmar	389	0.384	0.098	1.634	0.178
Other plans						389	2.578	1.034	6.247	0.038a
Disease site at diagnosis
Terminal ileum						389	1.350	0.612	3.042	0.460	389	1.246	0.732	2.104	0.414	389	-0.227	-0.847	0.392	0.472
Colon						389	0.812	0.385	1.762	0.590	389	1.581	0.756	3.247	0.216
History of CD-related complications
Intestinal fistula	389	0.307	0.098	0.976	0.042a
Intestinal obstruction	389	0.831	0.322	2.293	0.709
Extraintestinal abscess						389	5.766	1.277	25.741	0.020a
Anal fistula						389	0.747	0.350	1.509	0.431						389	0.142	-0.546	0.829	0.687
Joint pain	389	0.318	0.059	1.866	0.187
History of CD-related surgery	389	0.158	0.056	0.407	0.000						389	0.488	0.282	0.824	0.009b	389	-0.304	-0.908	0.299	0.323
Comorbidities
Gallbladder disease											389	3.812	1.343	11.494	0.013a
Kidney disease						389	5.015	0.826	31.142	0.070

^aP < 0.05.

^bP < 0.01. BMI: Body mass index; CD: Crohn’s disease; CI: Confidence interval; CMT: Conventional maintenance therapy; IMT: Infliximab maintenance therapy; OR: Odds ratio; SD: Standard deviation.