Efficacy and safety of anti-hepatic fibrosis drugs

doi:10.3748/wjg.v26.i41.6304

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Nov 7, 2020; 26(41): 6304-6321
Published online Nov 7, 2020. doi: 10.3748/wjg.v26.i41.6304

Table 1 Drugs currently in phase 3 investigation trials for the treatment of nonalcoholic steatohepatitis according to ClinicalTrials.gov

Drug name	Mechanism of action	Estimated completion	Study/identifier
Resmetirom (MGL-3196)	Thyroid hormone receptor agonist	March 2024	[MAESTRO-NASH] NCT03900429
Dapaglifozin	SGLT-2 inhibitor	November 2021	[DEAN] NCT03723252
Aramchol	SCD1 inhibitor	December 2024	[ARMOR] NCT04104321
Cenicriviroc	CCR2-CCR5 antagonist	October 2028	[AURORA] NCT03028740
Elafibranor	PPAR agonist	December 2021	[RESOLVE-IT] NCT02704403
Obeticholic acid	FXR agonist	October 2022	[REGENERATE] NCT02548351

CCR: Chemokine receptor; FXR: Farnesoid X receptor; PPAR: Peroxisome proliferator-activated receptor; SCD1: Stearoyl coenzyme A desaturase 1; SGLT-2: Sodium-glucose transport protein.

Citation: Damiris K, Tafesh ZH, Pyrsopoulos N. Efficacy and safety of anti-hepatic fibrosis drugs. World J Gastroenterol 2020; 26(41): 6304-6321
URL: https://www.wjgnet.com/1007-9327/full/v26/i41/6304.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i41.6304