Dynamic contrast-enhanced magnetic resonance imaging and diffusion-weighted imaging in the activity staging of terminal ileum Crohn's disease

Table 4 Receiver operating characteristic analysis results for the parameters for differentiating inactive Crohn’s disease from active Crohn’s disease

Parameter	AUC (CI)	Threshold	Sensitivity (CI)	Specificity (CI)	PPV (CI)	NPV (CI)	LR+ (CI)	LR- (CI)
Ktrans (min -1)	0.76 (0.61-0.91)	0.03	0.83 (0.66-0.93)	0.69 (0.39-0.90)	0.88 (0.71-0.96)	0.6 (0.33-0.83)	2.69 (1.18-6.17)	0.25 (0.11-0.55)
Kep (min -1)	0.68 (0.50-0.85)	0.19	0.69 (0.51-0.83)	0.69 (0.39-0.90)	0.86 (0.66-0.95)	0.45 (0.24-0.68)	2.23 (0.96-5.19)	0.45 (0.26-0.79)
Ve	0.78 (0.60-0.96)	0.29	0.83 (0.66-0.93)	0.85 (0.54-0.97)	0.94 (0.77-0.99)	0.65 (0.39-0.85)	5.39 (1.49-19.44)	0.20 (0.10-0.43)
ADC (× 10-3 mm2/s)	0.89 (0.78-1.00)	1.6	0.91 (0.76-0.98)	0.77 (0.46-0.94)	0.91 (0.76-0.98)	0.77 (0.46-0.94)	3.96 (1.46-10.74)	0.11 (0.04-0.34)
MaRIA	0.91 (0.82-1.00)	7.2	0.89 (0.72-0.96)	0.85 (0.54-0.97)	0.94 (0.78-0.99)	0.73 (0.45-0.91)	5.76 (1.60-20.71)	0.14 (0.05-0.35)
Ktrans + Kep + Ve	0.80 (0.62-0.98)	-	0.89 (0.72-0.96)	0.85 (0.54-0.97)	0.94 (0.78-0.99)	0.73 (0.45-0.91)	5.76 (1.60-20.71)	0.14 (0.05-0.35)
Ktrans + Kep + Ve + ADC	0.95 (0.85-1.00)	-	0.97 (0.83-1.00)	0.92 (0.62-1.00)	0.97 (0.83-1.00)	0.92 (0.62-1.00)	12.63 (1.92-83.09)	0.03 (0.00-0.22)

AUC: Area under the curve; CI: 95% confidence interval; NPV: Negative predictive value; PPV: Positive predictive value; LR+: Positive likelihood ratios; LR-: Negative likelihood ratios; ADC: Apparent diffusion coefficient; MaRIA: Magnetic Resonance Index of Activity.