Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism

Table 2 Relationships of human papillomavirus status according to ISH with risk factors for esophageal squamous cell carcinoma, n (%)

HPV	ALDH2 genotype						P value
	*1/*2 (n = 93)			*1/*1 + *2/*2 (n = 52)
Positive (n = 15)	10 (10.8)			5 (9.6)			1.00
Negative (n = 130)	83 (89.3)			47 (90.4)
	ADH1B genotype
	*1/*1 (n = 25)			*2 carrier (n = 120)
Positive (n = 15)	3 (12.0)			12 (10.0)			0.72
Negative (n = 130)	22 (88.0)			108 (90.0)
	Alcohol consumption
	Light – Rare (n = 46)			Heavy – Moderate (n = 99)
Positive (n = 15)	4 (8.7)			11 (11.1)			0.68
Negative (n = 130)	42 (91.3)			88 (88.9)
	Smoking habits
	Light – Rare (n = 60)			Heavy (n = 85)
Positive (n = 15)	5 (8.3)			10 (11.8)			0.59
Negative (n = 130)	55 (91.7)			75 (88.2)
	Genotype combinations
	A	B	C		D	E
Positive (n = 15)	0 (0.0)	5 (10.9)	3 (15.0)		7 (9.6)	0 (0.0)	0.87
Negative (n = 130)	5 (100.0)	41 (89.1)	17 (85.0)		66 (90.4)	1 (100.0)

A: ADH1B genotype (*1/*1), ALDH2 genotype (*1/*1); B: ADH1B genotype (*2 carrier), ALDH2 genotype (*1/*1); C: ADH1B genotype (*1/*1), ALDH2 genotype (*1/*2); D: ADH1B genotype (*2 carrier), ALDH2 genotype (*1/*2); E: ADH1B genotype (Any), ALDH2 genotype (*2/*2).