Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease

Table 2 Diagnostic performance of imaging studies for fibrosis assessment methods from studies made in patients with non-alcoholic fatty liver disease

	Population	Ref.	Cutoffs	Se	Sp	PPV	NPV	AUROC
TE [LSM (kPA)]	n = 291	[85]	≥ 8.2 kPa AF	90%	61%	NA	NA	0.870
			≥ 12.5 kPa AF	57%	90%	NA	NA	NA
	452	[56]	≥ 8.7 kPa AF	88%	63%	59%	90%	0.831
	142	[77]	≥ 11.7 kPa AF	86%	84%	75%	92%	0.880
	79	[83]	≥ 9.5 kPa AF	92%	63%	54%	94%	NA
MRE [LSM (kPA)]	142	[77]	≥ 4.8 kPa AF	74%	87%	74%	81%	0.890
	628	[63]	≥ 3.6 kPa AF	86%	91%	71%	93%	NA
	117	[97]	≥ 3.63 kPa AF	81%	89%	68%	97%	NA
	142	[98]	≥ 4.15 kPa AF	85%	92%	NA	NA	0.954
	102	[99]	> 3.64 kPa AF	92%	90%	NA	NA	0.957
ARFI [SWV (m/s)]	291	[85]	≥ 1.15 AF	90%	63%	NA	NA	0.840
			≥ 1.53 AF	59%	90%	NA	NA	NA
	57	[90]	≥ 1.45 AF	76%	68%	NA	NA	0.910
	32	[91]	≥ 1.3 AF	85%	83%	NA	NA	NA
	23		≥ 1.47 AF	100%	75%	NA	NA	0.942
	NASH	[92]
	54	[93]	≥ 1.77 AF	100%	91%	NA	NA	0.930

Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; AUROC: Area under the curve; TE: Transient elastography; MRE: Magnetic resonance elastography; ARFI: Acoustic radiation force impulse; LSM: Liver stiffness measurement; kPa: Kilopascal; SWV: Shear wave velocity; NASH: Non-alcoholic steatohepatitis; NF: No fibrosis; AF: Advanced fibrosis; NAF: Non-advanced fibrosis; NA: Not available.