Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis

Figure 3 Trends in fibrosis-4 and aspartate aminotransferase-to-platelet ratio index scores across 15 years prior to cirrhosis diagnosis among cases and controls. Trends in A: Fibrosis-4 and B: Aspartate aminotransferase-to-platelet ratio index scores, both done with locally weighted scatterplot smoothing trend. There is a gradual increase in both scores in the cirrhosis group compared to controls, ranging from 1.3 to 3 and 0.48 to 0.93 respectively.