Acetyl-11-keto-β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway

Figure 6 Acetyl-11-keto-β-boswellic acid inhibits gastric cancer tumor growth in vivo. Twenty nude mice were subcutaneously injected with BGC823 and SGC7901 cells. When tumor size was approximately 0.1 cm³, the nude mice were randomly divided into different groups (n = 5) to receive different treatments. A: Acetyl-11-keto-β-boswellic acid (AKBA) inhibits gastric cancer xenograft tumor growth in vivo; B: Tumor volume was measured, and the tumor growth curves were plotted; C: Body weight change in the nude mice treated with saline or AKBA; D: Western blot analysis of cyclooxygenase (COX)-2 protein expression in gastric cancer tissues of control and AKBA treated nude mice (100 mg/kg/d); E: Histogram representing the relative expression of COX-2 compared with that of GAPDH. ^aP < 0.05, ^bP < 0.01 vs control (saline). AKBA: Acetyl-11-keto-β-boswellic acid.