Acetyl-11-keto-β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway

Figure 3 Effects of acetyl-11-keto-β-boswellic acid on the expression of phosphatase and tensin homolog, cyclooxygenase-2, and p-Akt in gastric cancer cells. A: Expression levels of phosphatase and tensin homolog (PTEN), cyclooxygenase (COX)-2, and p-Akt in gastric cancer cells measured via Western blot analysis; B: Histograms showing the relative expression levels of PTEN and COX-2 compared with GAPDH, and p-Akt compared with Akt in gastric cancer cells. Each data point represents the mean ± SD from three independent experiments. ^aP < 0.05, ^bP < 0.01 vs control (0 µM). AKBA: Acetyl-11-keto-β-boswellic acid; PTEN: Phosphatase and tensin homolog; COX-2: Cyclooxygenase-2; GAPDH: Glyceraldehyde-phosphate dehydrogenase.