Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma

doi:10.3748/wjg.v26.i38.5759

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Oct 14, 2020 (publication date) through Dec 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2020; 26(38): 5759-5783
Published online Oct 14, 2020. doi: 10.3748/wjg.v26.i38.5759

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Figure 4 Relating the hallmarks of cancer to the molecular mechanisms of hepatitis B virus and delta virus hepatocarcinogenesis. Hepatitis B virus can activate all ten hallmarks of cancer using viral proteins (HBx, HBsAg, HBeAg, HBcAg) and DNA integration. Hepatitis delta virus has been linked to four hallmarks, primarily through molecular mechanisms manipulated by the large and small hepatitis delta virus antigens (L-HDAg and S-HDAg). HBV: Hepatitis B virus; HDV: Hepatitis delta virus; ER: Endoplasmic reticulum; ROS: Reactive oxygen species.

Citation: D'souza S, Lau KCK, Coffin CS, Patel TR. Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma. World J Gastroenterol 2020; 26(38): 5759-5783
URL: https://www.wjgnet.com/1007-9327/full/v26/i38/5759.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i38.5759