Risk prediction rule for advanced neoplasia on screening colonoscopy for average-risk individuals

Table 3 Existing risk prediction studies by design, age, exclusion of family history and previous colonoscopy

Ref.	Design	Positive family history excluded	Age for inclusion	Mean age (SD)	Included only first screening colonoscopy
Betés et al[25], 2003	Prospective	Yes	≥ 40	58 (8.6)	No1
Cai et al[27], 2012	Prospective	No	≥ 40	60 (11.1)	No1
Chen et al[33], 2014	Prospective	Yes	≥ 40	62.7 (9.7)	No1
Hong et al[34], 2017	Prospective	Yes	≥ 20	49.9 (9.3)	Yes
Imperiale et al[35], 2015	Prospective	No	50-80	57.3 (6.6)	Yes
Imperiale et al[36], 2016	Prospective	No	30-49	57.2 (6.6)	No2
Jung et al[24], 2017	Prospective	No	< 50	38.9 (5.3)	Yes
Kaminski et al[29], 2014	Retrospective	No	50-80	55.6 (5.2)	No2
Kim et al[37], 2019	Retrospective	No	< 50	38.9 (5.3)	Yes
Ladabaum et al[38], 2016	Prospective	Yes	50-80	Median (IQR) 58 (52 – 65)	No
Li et al[39], 2016	Prospective	No	40-75	52 (IQR 47 – 59)	No
Lin et al[40], 2016	Prospective	No	≥ 50	59.6 (8.1)	No1
Murchie et al[41], 2017	Retrospective	Yes	40-49	51.5	Yes
Park et al[42], 2017	Retrospective	No	50-59	44.8 (2.8)	Yes
Ruco et al[43], 2015	Prospective	No	50-74	58.3 (6.2)	No2
Schroy et al[44], 2015	Prospective	Yes†	50-79	74.7% aged 50-59	No
Sekiguchi et al[26], 2018	Retrospective	No	≥ 40	56 (40–88)	Yes
Sung et al[45], 2017	Prospective	No	≥ 50	57.6 (4.9)	No1
Tao et al, 2014[46]	Prospective	No	≥ 55	63.5 (6.7)	No1
Wong et al[45], 2016	Prospective	No	50-70	57.7 (4.93)	No
Yang et al[47], 2017	Retrospective	No	≥ 50	41.6 (8.3)	Yes
Yeoh et al[48], 2011	Prospective	No	≥ 16	54 (11.6)	No1
Current study	Prospective	Yes	≥ 50	61 (8)	Yes

Participants with a family history of colorectal cancer and/or colorectal polyps detected above the age of 60 were included. Those below the age of 60 were excluded. Included subjects with prior colonoscopic screening (≥ 5 yr¹ or ≥ 10 yr²).