Pediatric non-alcoholic fatty liver disease and kidney function: Effect of HSD17B13 variant

Table 2 Main features in patients without non-alcoholic fatty liver disease according to HSD17B13 genotypes

	HSD17B13 TT (n = 199)	HSD17B13 TA/AA (n = 167)	P value
Age, yr	10.36 ± 2.98	10.36 ± 3.20	0.89
Duration of obesity	2.96 ± 0.79	2.95 ± 0.96	0.94
BMI -SDS	4.41 ± 1.84	4.88 ± 2.51	0.24
Sex (male), %	50.5	55.5	0.68
SBP-SDS	1.08 ± 1.24	0.79 ± 1.20	0.09
DBP-SDS	0.18 ± 0.75	1.03 ± 1.15	0.64
W/Hr	0.61 ± 0.05	0.60 ± 0.05	0.21
ALT, U/L	22.95 ± 6.90	20.30 ± 6.56	0.003
AST, U/L	23.03 ± 4.92	21.35 ± 6.07	0.004
GGT, U/L	16.70 ± 5.80	17.38 ± 4.34	0.33
Total-Cholesterol, mg/dL	160.66 ± 27.11	161.84 ± 33.11	0.76
LDL-C, mg/dL	93.74 ± 24.59	98.10 ± 28.27	0.36
HDL-C, mg/dL	48.18 ± 15.28	45.96 ± 8.97	0.50
Triglycerides, mg/dL	96.90 ± 59.74	95.77 ± 38.79	0.87
Glycaemia, mg/dL	79.95 ± 7.34	80.52 ± 7.66	0.08
HOMA-IR	4.63 ± 3.16	5.16 ± 3.75	0.27
eGFR, mL/min/1.73 m2	187.34 ± 37.76	197.82 ± 39.78	0.007

ALT: Alanine transaminase; AST: Aspartate transaminase; BMI: Body mass index; DBP: Diastolic blood pressure; eGFR: Estimated glomerular filtration rate; HDL-C: High-density lipoprotein cholesterol; HOMA: Homeostasis model assessment; LDL-C: Low density lipoprotein cholesterol; SBP: Systolic blood pressure; SDS: Standard deviation score; W/Hr: Waist to height ratio.