Pediatric non-alcoholic fatty liver disease and kidney function: Effect of HSD17B13 variant

Table 1 Main features in patients with non-alcoholic fatty liver disease according to HSD17B13 genotypes

	HSD17B13 TT (n = 218)	HSD17B13 TA/AA (n = 100)	P value
Age, yr	10.72 ± 2.88	10.60 ± 2.80	0.67
BMI-SDS	2.98 ± 0.73	3.00 ± 0.75	0.85
Duration of obesity, yr	4.65 ± 1.93	4.64 ± 2.17	0.60
Sex (male), %	53.3	51.2	0.82
SBP-SDS	1.00 ± 1.15	1.12 ± 1.14	0.33
DBP-SDS	0.25 ± 0.89	0.30 ± 0.91	0.54
W/Hr	0.62 ± 0.05	0.63 ± 0.06	0.04
ALT, U/L	35.45 ± 21.69	30.60 ± 21.52	0.02
AST, U/L	26.86 ± 10.18	24.49 ± 8.86	0.01
GGT, U/L	20.42 ± 9.73	19.70 ± 9.49	0.45
Total-Cholesterol, mg/dL	160.13 ± 33.85	158.19 ± 30.80	0.55
LDL, mg/dL	95.84 ± 29.31	93.38 ± 23.93	0.40
HDL, mg/dL	44.07 ± 10.68	45.30 ± 11.24	0.67
Triglycerides, mg/dL	101.21 ± 51.36	99.92 ± 47.62	0.79
Glycaemia, mg/dL	83.05 ± 9.10	81.80 ± 8.44	0.14
HOMA-IR	6.19 ± 5.35	5.94 ± 3.86	0.62
eGFR, mL/min/1.73m2	186.71 ± 36.55	197.45 ± 34.92	0.01

ALT: Alanine transaminase; AST: Aspartate transaminase; BMI: Body mass index; DBP: Diastolic blood pressure; eGFR: Estimated glomerular filtration rate; GLM: General linear model; HDL-C: High-density lipoprotein cholesterol; HOMA: Homeostasis model assessment; LDL-C: Low density lipoprotein cholesterol; SBP: Systolic blood pressure; SDS: Standard deviation score; W/Hr: Waist to height ratio.