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©The Author(s) 2020.
World J Gastroenterol. Sep 21, 2020; 26(35): 5314-5327
Published online Sep 21, 2020. doi: 10.3748/wjg.v26.i35.5314
Published online Sep 21, 2020. doi: 10.3748/wjg.v26.i35.5314
Table 1 Summary of immune escape-associated mutations in the major hydrophilic region of hepatitis B surface antigen
| Region in major hydrophilic region | Mutation pattern |
| Upstream “a” determinant (aa 99-123) | sY100S, sQ101H/K/R, sM103I/T, sL109I/P/R, sP111L/Q/S, sG112K/R, sS114A/L/T, sT115A/N, sT116N, sS117G/N/R, sT118A/K/M/R/S/V, sG119E/R/T, sP120A/L/Q/S/T, sC121R/S, sK122R, sT123A/I/N/S/V |
| Within “a” determinant (aa 124-147) | sC124R/Y, sT125A/M, sI/T126A/N/P/S, sP127H/L/S/T, sA128T/V, sQ129N/H/P/R, sG130A/K/N/R/S, sT131A/I/K/N, sS132F/P, sM133I/L/T, sF/Y134H/L/R/S/V, sS136F/P/Y, sC137W/Y, sC139R/S/Y, sT140I, sK141E/R, sP142L, sD144A/E, sG145A/R, sC147R/Y |
| Downstream “a” determinant (aa 148-169) | sS154P, sA159G/V, sV168A |
- Citation: Huang BX, Liu Y, Fan ZP, Si LL, Chen RJ, Wang J, Luo D, Wang FS, Xu DP, Liu XG. Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations. World J Gastroenterol 2020; 26(35): 5314-5327
- URL: https://www.wjgnet.com/1007-9327/full/v26/i35/5314.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i35.5314