Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors

doi:10.3748/wjg.v26.i34.5074

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Sep 14, 2020 (publication date) through Nov 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2020; 26(34): 5074-5089
Published online Sep 14, 2020. doi: 10.3748/wjg.v26.i34.5074

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Figure 2 Metabolic enzyme mutations lead to the accumulation of oncometabolites, which competitively inhibit α-ketoglutarate-dependent dioxygenases. α-KG: α-ketoglutarate; AMLs: Acute myeloid leukemias; D-2HG: D-2-hydroxyglutarate; FH: Fumarate hydrase; HLRCC: Hereditary leiomyomatosis and renal cell cancer; IDH: Isocitrate dehydrogenase; LGGs: Low-grade gliomas; SDH: Succinate dehydrogenase.

Citation: Zhao Y, Feng F, Guo QH, Wang YP, Zhao R. Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors. World J Gastroenterol 2020; 26(34): 5074-5089
URL: https://www.wjgnet.com/1007-9327/full/v26/i34/5074.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i34.5074