Resveratrol alleviates intestinal mucosal barrier dysfunction in dextran sulfate sodium-induced colitis mice by enhancing autophagy

Figure 6 Expression levels of Beclin-1 and LC3B in dextran sulfate sodium induced chronic colitis. A: A substantial increase in the messenger ribonucleic acid expression level of LC3B and Beclin-1 was observed in the dextran sulfate sodium (DSS) + resveratrol treatment group compared with the DSS group (P < 0.05); B and C: The Western blotting showed that resveratrol treatment induced significant increases in the LC3-II/I ratio and Beclin-1 level in DSS-induced colitis mice; Mean grey level of Beclin-1 and LC3B protein level was increased in DSS + resveratrol treatment group. ^aP < 0.05. DSS: Dextran sulfate sodium; 5-ASA: 5-aminosalicylic acid; mRNA: Messenger ribonucleic acid; RES: Resveratrol.