Resveratrol alleviates intestinal mucosal barrier dysfunction in dextran sulfate sodium-induced colitis mice by enhancing autophagy

Figure 4 Histological staining showed colitis induced dysfunction. A: Dextran sulfate sodium group showed significant colonic mucosal damages, crypt depletion, infiltration of inflammatory cells into the mucosa and submucosa, loss of epithelial barrier. Resveratrol treatment group and 5-aminosalicylic acid could alleviate colitis-induced intestinal mucosal barrier dysfunction; and B: The histological score of resveratrol treatment group was lower than the dextran sulfate sodium group. ^aP < 0.05. DSS: Dextran sulfate sodium; 5-ASA: 5-aminosalicylic acid; RES: Resveratrol.