Exploring the food-gut axis in immunotherapy response of cancer patients

Figure 1 Gut microbiota impact on the efficacy of programmed cell death protein 1 blockade. Specific gut microbiota profiles correlates with response to programmed cell death protein 1 (PD-1) blockade in tumor patients. Fecal microbioma transplantion (FMT) from responders into mice, improve responses to anti-PD-1 treatment and correlated with increased anti-cancer CD8⁺ cells in the tumour environment. Mice receiving FMT from non-responders’ patients did not respond to anti-PD-1 therapy, and tumour microenvironment is enriched of immune suppressive CD4⁺ regulatory T cells. PD-1: Programmed cell death protein 1; FMT: Fecal microbioma transplantion; Tregs: Regulatory T cells.