Neutrophil to lymphocyte ratio and albumin bilirubin grade in hepatocellular carcinoma: A systematic review

Table 2 Studies describing the relation between hepatocellular carcinoma and albumin bilirubin grade in the last 5 years

Ref.	Type	Patients/Studies (n)	Summary of main clinical points
Johnson et al[66]	Retrospective	6410	ALBI was developed as a simple model to assess liver function, based on 1,313 patients with HCC of all stages from Japan that involved only serum bilirubin and albumin levels. ALBI was then tested using similar cohorts from other geographical regions (n = 5097). The ALBI grade was found to offer a simple, evidence-based, objective, and discriminatory method of assessing liver function in HCC. ALBI was tested in an international setting. ALBI eliminated the need for subjective variables such as ascites and encephalopathy, a requirement in the conventional CTP grade
An et al[122]	Retrospective	251	ALBI grade predicted long-term outcomes for HCV-related HCC patients after ultrasound-guided percutaneous microwave ablation (US-PMWA)
Ni et al[123]	Retrospective	546	ALBI grade resulted in reliable efficacy for prediction of individualized OS in patients with intermediate-stage HCC after transarterial chemoembolization combined with microwave ablation (TACE-MWA)
Geng et al[124]	Meta-analysis	11365 patients 20 studies	In patients with HCC after liver resection, higher ALBI grade was associated with poorer OS and RFS. Correlation between ALBI grade and poor long-term survival was not altered in different geographical areas, sample sizes, follow-up duration, and quality scores
Huang et al[125]	Prospective randomized controlled trial	830	ALBI grade was used to stratify patients to compare the clinical application values of contrast-enhanced ultrasound, computed tomography/magnetic resonance-CEUS, and three-dimensional ultrasound-CEUS. Fusion imaging (FI) techniques in the assistance of thermal ablation for HCC. The FI techniques were more suitable in patients with ALBI grade 2 and 3
Soydal et al[126]	Retrospective	86	Patients with low ALBI and NLR survive longer after TACE for unresectable HCC
Palmer et al[127]	Prospective randomized controlled trial	85	Tumour burden and liver function represented in the ALBI grade are useful tools in HCC patient selection for selective internal radiation therapy
Hatanaka et al[128]	Retrospective	93	ALBI grade was a good predictive factor affecting the incidence of fatigue and decreased appetite in HCC patients treated with Lenvatinib
Xu et al[129]	Meta-analysis	19805 patients 8 studies	The ALBI grade has the potency of becoming an independent prognostic factor in patients with HCC
Ho et al[130]	Retrospective	2186	Newly proposed ALBI-HOME model; is based on ALBI grade, serum AFP, total tumour volume, ascites, performance status, and vascular invasion or metastasis. It was associated with the best prognostic ability among different HCC staging systems to predict survival in patients beyond Milan criteria; its ability remained consistently stable in different treatment subgroups and viral aetiologies
Wu et al[131]	Retrospective	134	In HBV related HCC, ALBI grades were significantly associated with OS and RFS. Multivariate analyses further revealed ALBI grades were independent predictors for survival
Mai et al[132]	Retrospective	1055	In HBV-related HCC patients who underwent hepatectomy, ALBI- aspartate aminotransferase-platelet ratio index (APRI) score is a novel and effective predictive model of PHLF for HBV-related HCC patients, and its accuracy in predicting the risk of PHLF is better than that of CTP, ALBI and APRI scores
Kornberg et al[133]	Retrospective	123	Posttransplant HCC recurrence rates were 10.5%, 15.9%, and 68.2% in ALBI grade 1, 2, and 3, respectively. ALBI grades 1 or 2 were identified as an independent predictor of RFS. ALBI grade 3 proved to be the strongest indicator of microvascular invasion (MVI). ALBI grade provided the best discriminative capacity in selecting liver recipients with low oncological risk profile
Lin et al[134]	Retrospective	383	Independent predictors for HCC recurrence were ALBI grades 2 and 3. Independent risk factors for poor survival were ALBI grades 2 and 3. Patients whose deteriorated ALBI grades 5 years after resection had adverse RFS outcomes compared to those with constant and improved ALBI grades. In subgroup analysis, patients with post-operative 5th-year ALBI grades 2 and 3 had significantly poorer RFS and OS than those with grade 1 among patients with low post-operative 5th-year AFP (< 15 ng/ML)
Ye et al[135]	Retrospective	300	Postoperative ALBI grade could predict the prognosis of patients with HCC after hepatectomy
Zhang et al[136]	Retrospective	544	Combination of ALBI grade and the fibrosis-4 index (FIB-4) predicted HCC patient outcomes after liver resection. A high ALBI-FIB-4 score was associated with a high incidence of postoperative recurrence and mortality
Ho et al[137]	Retrospective	123	A comparison among ALBI grades at the start of Lenvatinib for treatment for unresectable HCC identified decline in hepatic function in the early stage ( ≤ 4 weeks, especially within 2 weeks)
Hiraoka et al[138]	Retrospective	3690	A proposed ALBI-based nomogram of BCLC system was found to be a feasible strategy to estimate the survival of individual HCC patient except for very early stage patients
Takada et al[139]	Retrospective	190	Baseline ALBI was a predictor to direct candidates for second-line treatment after sorafenib in unresectable HCC
Ni et al[140]	Retrospective	349	Platelet ALBI (PALBI) grade demonstrated significant greater area under the curve values than ALBI grade or CTP class in predicting 1-, 3- and 5-year OS in patients with large HCCs after transarterial chemoembolization combined with microwave ablation (TACE-MWA)
Nguyen et al[141]	Retrospective	110	Baseline ALBI grade is an independent predictor of survival in patients treated with sorafenib
Ho et al[142]	Retrospective	1655	ALBI grade is feasible in predicting survival in HCC patients within the Milan criteria, and helps identify high-risk patients who need timely liver transplantation
Lee et al[143]	Retrospective	570	ALBI is associated with survival in BCLC stage B HCC patients undergoing TACE. ALBI can be applied to select patients who can get most benefit from TACE
Hiraoka et al[144]	Retrospective	84	Good hepatic function represented by the ALBI grades at introduction of the initial tyrosine kinase inhibitor (TKI) is a requirement for improved prognosis of unresectable HCC undergoing TKI sequential therapy, including Lenvatinib (LEN)
Elshaarawy[145]	Retrospective	1910	Validation study for the proposed modified albumin-bilirubin-TNM (mALBI-T) grade as a prognostic model for patients with HCC. ALBI-T grade was a superior prognostic tool that selects patients with HCC who have better liver reservoir and tumour stage
Ueshima et al[146]	Retrospective	82	Patients with CTP score of 5 and ALBI grade 1 predicted a higher response rate and lower treatment discontinuation due to adverse events by Lenvatinib treatment
Sonohara et al[147]	Retrospective	305	Platelet-albumin-bilirubin (PALBI) grade can be used for assessing perioperative risks for hepatectomy for HCC
Antkowiak et al[148]	Retrospective	1000	Median OS for ALBI 1, 2, and 3 grades was 46.7, 19.1, and 8.8 months, respectively. Median OS for CTP A, B, and C was 21.7, 11.3, and 6.0 mo, respectively. ALBI outperforms CTP in survival prognosis in yttrium-90 radioembolization (Y90) treated patients. On sub-analyses, serum albumin (not bilirubin) appears to be the main driver of survival prediction
Honmyo et al[149]	Retrospective	1270	ALBI and Albumin-Indocyanine Green Evaluation (ALICE) grading systems could estimate the liver function of patients with HCC. Regarding hepatectomy patients, the ALICE grade was a more suitable model than the ALBI grade
Khalid et al[150]	Retrospective	71	Mean ALBI score in the study was -1.59 ± 0.69, with the majority (49. 2 %) falling in grade 2. The mean duration of survival at the last follow up was of 12.1 ± 12.14 mo (1-49). Univariate analysis showed serum albumin (P = 0.003), serum bilirubin (P = 0.018), CTP score (P = 0.019), ALBI grade (P = 0.001) and presence of varices (P = 0.04) to be the main predictors of 6 months survival after TACE. On Cox analysis, only ALBI score (P = 0.038) showed statistically significant association
Luo et al[151]	Retrospective	132	Combined albumin- bilirubin (ALBI) grade and aspartate aminotransferase-to-platelet count ratio index (APRI) score and presence of microvascular invasion correlated with postoperative mortality. The area under the curve for ALBI-APRI score was significantly higher than either ALBI or APRI alone for predicting both postoperative recurrence and mortality. ALBI-APRI score may be a predictor for the prognosis of patients with HCC within Milan criteria following liver resection
Lu et al[152]	Retrospective	2038	Study aimed to identify liver function reserve in CTP class A HCC patients. The platelet-albumin-bilirubin (PALBI) was discriminatory for risk stratification of PHLF grade B/C and OS in CTP class A HCC patients following resection
Lee et al[153]	Retrospective	6669	The median OS durations of PALBI grade1 (38.4%), grade2 (33.2%), and grade3 (28.4%) patients were 81, 30, and 5 mo, respectively (P < 0.001). The PALBI grade had a larger area under the receiver operator characteristic curve (AUC) than did the CTP class, MELD score, and ALBI grade. Moreover, the PALBI and ALBI grades enabled sub-classification of CTP A patients (P < 0.001). In a multivariate analysis, the PALBI and ALBI grades were significant risk factors for OS (P < 0.05). According to treatment modality, the PALBI grade was predictive of OS in patients receiving TACE or supportive care. The ALBI grade was predictive of OS in patients undergoing surgical resection or radiofrequency ablation
Su et al[154]	Retrospective	594	In HCC after stereotactic body radiation therapy CTP class was significantly related to OS, with a median OS of 29.9 mo in CTP-A, 11.5 in CTP-B. ALBI grade was also significantly related to OS, with a median OS of 53.0 mo in ALBI-1, 19.5 mo in ALBI-2, and 6.5 mo in ALBI-3. The ALBI score was a more objective, discriminatory and evidence-based approach in CTP-A groups
Mai et al[155]	Retrospective	1044	The preoperative aspartate aminotransferase-to-platelet-ratio index (APRI) score for predicting PHLF was significantly more accurate than CTP, MELD, or ALBI scores
Chen et al[156]	Retrospective	271	In patients with very early stage HCC after radiofrequency ablation (BCLC stage 0 HCC). ALBI grade 2 or 3 were the independent risk factors predicting worse OS. Multivariate analysis showed that ALBI grade 2 or 3 was the only one independent risk factor associated with poor recurrence-free survival (RFS) after RFA. Most of the subgroup analyses also demonstrated that patients with ALBI grade 2 or 3 had poorer OS and RFS than those with ALBI grade 1
Zhong et al[157]	Retrospective	838	ALBI grade performs at least no worse than CTP score regarding survival prediction for HCC receiving TACE
Sonohara et al[158]	Retrospective	273	Combined albumin-bilirubin-TNM (ALBI-T) score in CTP class A HCC could predict perioperative risk in hepatectomy such as longer operation time and excessive intraoperative blood loss
Xu et al[159]	Systematic review	22911 patients; 32 studies	High pre-treatment ALBI is associated with poor OS and poor DFS. Analysis was stratified into subgroups, such as treatment methods, sample size, geographic area, and ALBI grade, the significant correlation in ALBI and poor long-term survival was not altered. High ALBI should be treated as an ideal predictor during HCC therapy
Lee et al[160]	Retrospective	465	Following HCC surgical therapy, ALBI grade ≥ 2 was demonstrated to be an independent risk factor for early recurrence
Tada et al[161]	Retrospective	567	Time-dependent receiver operating characteristic analysis showed that ALBI grade was better than CTP score in predicting overall survival in patients with advanced HCC who received sorafenib therapy
Russolillo et al[162]	Retrospective	400	In HCC patients treated with resection, the albumin-indocyanine green evaluation (ALICE) model, correlated better with ALBI than with CTP score. It can be used as measure for liver function
Mohammadi et al [163]	Retrospective	124	ALBI is a more sensitive marker of liver function than CTP in the setting of mild dysfunction. Using ALBI identified a subset of patients that have significantly better outcomes from Y-90 radioembolization than previously identified with CTP in HCC patients
Fang et al[164]	Retrospective	2285	Patients with single large HCC (SLHCC) had an overall survival rate intermediate to those of the BCLC-A and BCLC-B groups. It is suggested that the SLHCC group could be classified as occupying a different stage from the BCLC stages A and B. ALBI was able to stratify SLHCC into a different prognostic group
Ho et al[165]	Retrospective	1038	ALBI was a feasible marker for HCC tumour recurrence after resection
Casadei Gardini, et al [166]	Retrospective	416	ALBI score identified patients with higher risk of HCC after treatment with DAAs
Zhang et al[167]	Retrospective	338	The ALBI grade showed good predictive ability for PHLF in HCC patients across different BCLC stages. However, the ALBI grade was only a significant predictor of OS in BCLC stage 0/A patients and failed to predict OS in BCLC stage B/C patients
Mohammed et al[168]	Retrospective	123	ALBI score before TACE provided objective prognostication for development of acute-on-chronic liver failure (ACLF)
Carling et al[169]	Retrospective	49	Platelet-albumin-bilirubin index (PALBI) grade 1 and 2 differentiated survival in CTP-A patients treated with TACE
Jaruvongvanich et al[170]	Retrospective	900	Platelet-albumin-bilirubin index (PALBI) was found to be the most accurate prognostic models among to predict mortality and recurrence in HCC patients when compared to. CTP score, Fibrosis-4 (FIB-4) score, model for end-stage liver disease (MELD) score, ALBI and AST to platelet ratio index (APRI)
Amisaki et al[171]	Retrospective	136	In HCC patients who underwent curative resection Pre- and post-operative ALBI grade predicted patients' overall survival, and recurrence-free survival. Post-operative ALBI grade was associated with patients' surgical factors of repeated hepatic resection, intra-operative bleeding and surgery duration. Post-operative ALBI grade, rather than pre-operative ALBI grade, was an independent predictive factor of long-term outcome of CTP class A patients with HCC
Cai et al[172]	Retrospective	389	The Cancer of the Liver Italian Program (CLIP) score is commonly used for prognosis prediction of HCC. Combined ALBI-CLIP scoring system retained the prognostic value of the CLIP in HBV-related HCC treated with TACE therapy
Li et al[173]	Retrospectives	475	A high combined ALBI- platelet-to-lymphocyte ratio (ALBI-PLR) score is associated with a high incidence of postoperative recurrence and mortality in HBV-related HCC patients after liver resection
Ho et al[174]	Retrospective	174	Among CTP class A HCC patients receiving radiotherapy, the PALBI and ALBI grade were better prognostic tools than the CTP score
Murray et al[175]	Retrospective	102	The baseline ALBI grade was more discriminating than the CTP score in predicting OS and toxicity in patients with CTP class A liver disease patients with HCC treated with stereotactic body radiation therapy (SBRT)
Okuda et al[176]	Retrospective	38	ALBI grade was a prognostic factor for survival from brain metastases in HCC patients
Luo et al[177]	Retrospective	785	The prognostic significance of the PALBI grade for postoperative recurrence and mortality was maintained when stratified by the TNM stage. The preoperative PALBI grade is a surrogate marker for the postoperative prognosis in patients with HBV-related HCC after liver resection
Ho et al[178]	Retrospective	645	ALBI revealed the highest homogeneity and lowest value among twelve invasive models, indicating a better prognostic performance
Lei et al[179]	Retrospective	395	ALBI scores exhibited parallel tendencies to the CTP and MELD scores in HBV-ACLF, HBV-LC, and HBV-HCC patients; thus, ALBI grading may be a simple but applicable method for the evaluation of the functional status of patients with HBV-related end-stage liver diseases
Na et al[180]	Retrospective	2099	ALBI grade provided better prognostic performance in survival analysis and better distribution of the grades than C-P grade in HCC, suggesting that ALBI grade could be a good alternative grading system for liver function in patients with HCC
Chong et al[181]	Retrospective	63	Liver resection offered superior disease-free survival to microwave ablation (MWA) in patients with HCC. The ALBI grade could identify patients with worse liver function who might gain survival advantage from MWA
Gkika et al[182]	Retrospective	40	In HCC patients with BCLC classification stage B or C who were treated with SBRT in 3-12 fractions. A higher ALBI grade and CTP at baseline correlated with a higher incidence of acute and late radiation toxicities
Chen et al[183]	Retrospective	887	In patients with HCC with compensated liver function, a combination of albumin-bilirubin grade and platelet count (ALBI-PLT) score of 2 predicted a very low risk of variceal haemorrhage; therefore, endoscopic screening for esophageal varices is not recommended for these patients
Hiraoka et al[184]	Retrospective	46681	Study compared between Japan Integrated Staging (JIS), consisting of CTP classification and TNM staging (TNM), modified JIS (m-JIS), consisting of liver damage grading and TNM, and ALBI-TNM (ALBI-T), consisting of ALBI grading and TNM. The predictive value for prognosis of ALBI-T was found to be equal to that of JIS and m-JIS
Yoh et al[185]	Retrospective	207	A preoperative prognostic model using objective variables involving two parameters 18F-fluorodeoxyglucose-positron emission tomography (18F-FDG-PET) and the albumin-bilirubin (ALBI) grade was useful for estimating the prognosis of selected patients with solitary HCC
Dong et al[186]	Retrospective	654	ALBI grade significantly influenced the overall survival and cumulative recurrence rates. Furthermore, the ALBI score was significantly related to the degree of liver cirrhosis and serum γ-glutamyl transpeptidase (GGT) concentration in solitary HCC cases within the Milan criteria and CTP A cirrhosis. Additionally, the combination of the ALBI score and serum GGT concentration contributed to the prognosis prediction in this cohort
Li et al[187]	Retrospective	258	Postoperative worsening of ALBI grade was associated with increased recurrence and poorer overall survival for patients with HBV-related HCC within the Milan criteria
Hsu et al[188]	Retrospective	1935	Risk Assessment for early Mortality (RAM) scoring system is a developed tool for assessing early mortality after hepatectomy for HCC. RAM score was obtained by the summation of the scores of 6 independent variables, namely diabetes mellitus (1), albumin ≤ 3.5 g/DL (2), α-fetoprotein > 200 ng/ML (2), major resection (1), blood loss > 800ML (1), and major surgical complications (3). RAM classes were developed by visual inspection of the Kaplan-Meier survival curves, and RAM class I, II, and III corresponded to RAM scores of 0–6, 7–9, and 10, respectively. This study demonstrated that RAM score is an effective and user-friendly bedside scoring system to predict early mortality and early recurrence after hepatectomy for HCC. In addition, the predictive capability of RAM score is superior to ALBI and MELD scores
Hiraoka et al[189]	Retrospective	647	Study 1 comprised of 212 Barcelona clinic liver cancer stage-B (BCLC-B) HCC patients classified as CTP-A who had received repeated TACE treatments (r-TACE) (naïve: recurrence = 66:146). Study 2 comprised of 435 patients with unresectable HCC classified as CTP-A in whom sorafenib was introduced (native:recurrence = 37:398). The rate of patients with downgraded hepatic function with repeated TACE procedures, especially with regard to ALBI-grade, was not low. ALBI-grade was shown to be a better hepatic function assessment tool than CTP in patients receiving sorafenib treatment. Strict judgment of TACE-refractory status in patients with unresectable HCC is needed to improve prognosis before downgrading the hepatic function
Pinato et al[190]	Retrospective	387	Multi-centre retrospective study, the albumin-bilirubin grade highlights the interplay between liver reserve and immune dysfunction as prognostic determinants in HIV-associated HCC
Oh et al[191]	Retrospective	368	Among patients with very early-stage HCC treated with RFA, ALBI grade was a good stratifying biomarker. ALBI grade was better tool for assessing liver function than CTP score for very early-stage HCC treated with RFA
Lo et al[192]	Retrospective	152	ALBI was a predictor for both survival and liver toxicity. Complementary use of CTP and ALBI score could predict the risk of post stereotactic ablative radiation therapy (SABR) liver toxicity. Further prospective studies are necessary before use of the ALBI score can become part of daily practice
Chong et al[193]	Retrospective	488	Liver resection offered superior survival to RFA in patients with BCLC stage 0/A HCC. The ALBI grade could identify those patients with worse liver function who did not gain any survival advantage from curative liver resection
Lee et al[194]	Retrospective	404	ALBI can stratify the patients with advanced HCC for the second-line trials or salvage therapy
Hansman et al[195]	Retrospective	180	ALBI grades are accurate survival metrics in high-risk patients undergoing conventional TACE for HCC
Zou et al[196]	Retrospective	229	The ALBI score showed superior predictive value of post-operative outcomes over CTP score
Ho et al[197]	Retrospective	881	ALBI grade served as an objective and feasible surrogate to predict the prognosis of HCC patients undergoing TACE
Hiraoka et al[198]	Retrospective	3495	ALBI grade is a useful and easy classification system for assessment of hepatic function for therapeutic decision making
Kao et al[199]	Retrospective	622	ALBI grade offered personalized long-term survival data for patients with early-stage HCC who undergo RFA
Gui et al[200]	Retrospective	117	ALBI grade demonstrated clear survival discrimination that is superior to CTP class among HCC patients treated with radio-embolization,particularly within the subgroup of CTP class A patients
Kuo et al[201]	Retrospective	260	ALBI grade at baseline and also ALBI grade change during treatment predicted the prognosis of advanced HCC patients who received sorafenib
Waked et al[202]	Retrospective	3030	The ALBI grade categorised patients receiving TACE into three clear prognostic groups, thereby emphasising the importance of underlying liver function in the outcome of TACE
Pinato et al[203]	Retrospective	447	The ALBI grade at sorafenib discontinuation identified a subset of patients with prolonged stability of hepatic reserve and superior survival. This may allow improved patient selection for second-line therapies in advanced HCC
King et al[204]	Retrospective	448	Patients with ALBI grade > 1, CTP class B or poor performance status seem to derive limited benefit from sorafenib treatment
Li et al[205]	Retrospective	491	The ALBI grade added superior prognostic value compared to CTP class in patients with HCC who underwent liver resection
Ma et al[206]	Retrospective	318	ALBI grade predicted OS in patients with early-HCC. Reclassification of CTP class according to ALBI grade might improve the management of HCC
Liu et al[207]	Retrospective	3182	ALBI grades assess liver dysfunction in HCC. The PALBI grade is consistently better in all patients, in patients with minimally decreased liver function, and in patients receiving different aggressive therapies
Pinato et al[208]	Retrospective	2426	In this large, multi-centre retrospective study, the ALBI grade satisfied the criteria for accuracy and reproducibility following statistical validation in Eastern and Western HCC patients, including those treated with TACE. Consideration should be given to the ALBI grade as a stratifying biomarker of liver reserve in routine clinical practice
Hiraoka et al[209]	Retrospective	754	ALBI grade is simple and useful for prediction of prognosis and therapy decision-making in the heterogeneous population of BCLC stage B patients
Chan et al[210]	Retrospective	1973	The ALBI grade performs as well as the CTP grade when integrating into the CLIP system
Edeline et al[211]	Retrospective	1019	ALBI should be a stratifying factor in trials of systemic therapy
Hickey et al[212]	Retrospective	428	ALBI grade outperforms CTP class at discriminating survival in patients receiving TACE or (90) Y radioembolization. ALBI grade is also valuable in patients with moderate liver dysfunction and BCLC stage B disease
Wang et al[213]	Retrospective	1242	The ALBI grade predicted PHLF and OS in patients with HCC undergoing liver resection with curative intent more accurately than the CTP class
Chan et al[214]	Retrospective	3696	The ALBI grade performed as well as CTP class when integrated into the BCLC staging system in terms of predicting clinical outcome of HCC regardless of regions, aetiology, and treatment options
Hiraoka et al[215]	Retrospective	2584	ALBI grade was found to be superior for distinguishing patients with better hepatic function. ALBI-TNM scoring may be a better total prognostic scoring system for predicting survival of Japanese patients with HCC
Ogasawara et al[216]	Retrospective	89	Sorafenib may be indicated for all patients with advanced HCC and ALBI grade 1 and for some with ALBI grade 2. The subdivision of patients with ALBI grade 2 increases the utility of ALBI in identifying patients indicated for sorafenib therapy

ALBI: Albumin bilirubin grade; HCC: Hepatocellular carcinoma ; CTP: Child turcotte pugh score; HCV: Hepatitis C virus; US-PMWA: Ultrasound-guided percutaneous microwave ablation; TACE-MWA: Transarterial chemoembolization combined with microwave ablation; OS: Overall survival; RFS: Recurrence free survival; CEUS: Contrast-enhanced ultrasound; NLR: Neutrophil lymphocyte ratio; SIRT: Selective internal radiation therapy; PHLF: Post-hepatectomy liver failure; BCLC: Barcelona clinic liver cancer staging system; MELD: Model for end-stage liver disease; RFA: Radiofrequency ablation; DAAs: Direct-acting antivirals; PALBI: Platelet-albumin-bilirubin index; FIB-4: Fibrosis-4 ; APRI: AST to platelet ratio index; CLIP: Cancer of the liver Italian program; DFS: Disease free survival; HBV: Hepatitis B virus; AUC: Area under the curve.