Acute liver failure and death predictors in patients with dengue-induced severe hepatitis

Table 2 Regression analysis of the factors associated with acute liver failure from dengue-induced severe hepatitis

Parameters	Univariate analysis			Multivariate analysis
	Odds ratio	95%CI	P value	Adjusted odds ratio	95%CI	P value
Baseline demographic information
Age	1	0.9-1.0	0.044a	0.9	0.9-1.0	0.033b
Male sex	0.7	0.3-2.1	0.57	3.9	0.5-30.1	0.193
Hematological parameters change with response to dengue severity
Hematocrit	1	0.9-1.0	0.624	-	-	-
WBC count	1	1.0-1.0	0.419	-	-	-
Percentage of neutrophils	1.1	1.0-1.1	0.001c	-	-	-
Platelet count	1	1.0-1.0	0.907	-	-	-
Liver status at diagnosis of DISH
Total bilirubin	1.3	1.0-1.6	0.026d	-	-	-
SGPT	1	1.0-1.0	0.001e	-	-	-
INR	23.7	5.0-111.9	< 0.001f	-	-	-
Albumin	0.1	0.04-0.4	< 0.001g	0.7	0.2-3.2	0.696
Creatinine	2.2	1.3-3.9	0.006h	-	-	-
MELD score	1.3	1.2-1.4	< 0.001i	1.3	1.1-1.5	< 0.001j
Presence of liver comorbidity	3.8	1.1-13.9	0.042k	4.5	0.4-48.6	0.215

^aP < 0.05.

^bP < 0.05.

^cP = 0.001.

^dP < 0.05.

^eP = 0.001.

^fP < 0.001.

^gP < 0.001.

^hP < 0.05.

ⁱP < 0.001.

^jP < 0.001.

^kP < 0.05. DISH: Dengue-induced severe hepatitis; WBC: White blood cell; INR: International normalized ratio; SGPT: Serum glutamate-pyruvate transaminase; MELD: Model for End-Stage Liver Disease; CI: Confidence interval.