Acute liver failure and death predictors in patients with dengue-induced severe hepatitis

Table 1 Laboratory profiles at initial presentation

Laboratory parameters	All DISH patients (n = 151)	DISH without ALF (n = 134)	DISH with ALF (n = 17)	P value
Hematocrit (%)	41.0 ± 7.8	41.1 ± 7.7	40.2 ± 8.8	0.833
WBC (× 103/μL)	5.6 ± 3.8	5.5 ± 3.8	6.3 ± 3.9	0.379
Neutrophil (× 103/μL)	3.2 ± 2.8	3.0 ± 2.7	4.5 ± 3.0	0.461
Lymphocyte (× 103/μL)	1.5 ± 1.1	1.6 ± 1.1	1.1 ± 7.0	0.461
AL (× 103/μL)	0.4 ± 0.7	0.4 ± 0.8	0.2 ± 0.2	0.501
Platelet (× 1012/μL)	56.9 ± 76.5	57.2 ± 75.0	54.9 ± 89.9	0.190
INR	1.4 ± 0.7	1.2 ± 0.3	2.4 ± 1.0	0.004c
Creatinine (mg/dL)	1.0 ± 1.0	0.9 ± 0.9	1.9 ± 1.4	0.134
Albumin (g/dL)	3.6 ± 0.6	3.7 ± 0.5	3.0 ± 0.5	0.136
Total bilirubin (mg/dL)	2.0 ± 4.6	1.4 ± 1.7	6.3 ± 11.5	0.272
SGOT (U/L)	1547.0 ± 2254.3	1130.6 ± 1302.5	4804.3 ± 4540.4	0.437
SGPT (U/L)	694.3 ± 725.1	590.8 ± 493.6	1510.5 ± 1451.6	0.369
ALP (U/L)	112.0 ± 105.5	108.7 ± 108.5	138.1 ± 75.7	0.157
MELD score	12.3 ± 8.3	9.7 ± 4.7	24.5 ± 10.2	< 0.001d

^cP < 0.005.

^dP < 0.001. AL: Atypical lymphocyte; DISH: Dengue-induced severe hepatitis; ALF: Acute liver failure; WBC: White blood cell; INR: International normalized ratio; SGOT: Serum glutamate-oxaloacetate transaminase; SGPT: Serum glutamate-pyruvate transaminase; ALP: Alkaline phosphatase; MELD: Model for End-Stage Liver Disease.