Development of a novel score for the diagnosis of bacterial infection in patients with acute-on-chronic liver failure

Table 3 Diagnostic accuracy of procalcitonin, C-reactive protein, white blood cells, and proportion of neutrophils for the diagnosis of infection in liver failure

	Cut offs	Sensitivity (%)	Specificity (%)	PLR	NLR	PPV (%)	NPV (%)	P value	AUROC
PCT	≥ 1.01	42.60	78.80	2.01	0.73	61.01	63.81	< 0.0001	0.637
CRP	≥ 17.5	63.91	67.28	1.95	0.54	60.33	70.54	< 0.0001	0.692
WBC	≥ 7.90	47.93	79.72	2.36	2.36	64.79	66.28	< 0.0001	0.638
N%	≥ 73.8	55.03	76.50	2.34	0.59	64.58	68.60	< 0.0001	0.674

PCT: Procalcitonin; CRP: C-reactive protein; WBC: White blood cell count; N%: Proportion of neutrophils; PLR: Positive likelihood ratio; NLR: Negative likelihood ratio; PPV: Positive predictive value; NPV: Negative predictive value; AUROC: Area under the receiver operating characteristic curve.