Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma

Table 4 Univariate and multivariate analysis of factors associated with extrahepatic metastasis

	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
BCLC stage (0 vs A, B)	2.93 (1.38–6.20)	0.003
mUICC stage (I vs II, III)	2.04 (1.04–3.96)	0.034
Post-RFA complication (fever, abscess)	2.78 (1.31–5.92)	0.050
Presence of intra-hepatic recurrence	48.8 (6.68–356.63)	0.000
ALP > 97 U/L	2.29 (1.23-4.26)	0.008
1st recurrence free survival < 2 yr	2.88 (1.54-5.38)	0.001	2.44 (1.16-5.14)	0.019
Ratio of ablation zone and tumor size < 2	3.84 (1.76-8.39)	0.001	3.33 (1.34-8.27)	0.010
Presence of tumoral thrombosis	2.57 (1.13-5.84)	0.024
AFP > 400 IU/mL at 1st recurrence	4.52 (2.03-10.07)	0.000	3.35 (1.33-8.43)	0.010
mUICC stage > 2 at 1st recurrence	2.49 (1.22-5.06)	0.012

OR: Odds ratio; CI: Confidence interval; BCLC: Barcelona Clinic Liver Cancer; mUICC: Modified Union for International Cancer Control; RFA: Radiofrequency ablation; ALP: Alkaline phosphatase; AFP: Alpha-fetoprotein.