Clinical characteristics and risk factors for liver injury in COVID-19 patients in Wuhan

Table 2 Comparison of laboratory parameters between the two groups

Test	Normal liver function group	Abnormal liver function group	Normal ranges	P value
	Biochemical parameters
TBil	8.78 ± 3.73	12.66 ± 6.89	2-20.4 µmol/L	< 0.001
ALT	17.42 ± 8.05	69.74 ± 178.37	7-40 U/L	0.011
AST	18.96 ± 5.58	72.29 ± 269.68	13-35 U/L	0.083
GGT	17.51 ± 8.3	83.25 ± 93.48	7-45 U/L	< 0.001
ALP	49.96 ± 17.85	57.52 ± 42.16	40-150 U/L	0.330
Total protein	67.87 ± 7.39	67.31 ± 7.42	65-85 g/L	0.594
Albumin	40.70 ± 4.82	37.85 ± 4.95	40-55 g/L	< 0.001
Globulin	27.17 ± 5.92	29.46 ± 6.12	20-40 g/L	0.008
	Hematological parameters
WBC	5.11 ± 2.15	6.04 ± 2.78	3.5-9.5 × 109/L	0.011
Neutrophils	63.23 ± 13.23	71.45 ± 12.92	40-75%	< 0.001
Hemoglobin	128.31 ± 15.98	129.00 ± 18.93	12-160 g/L (male); 110-150 g/L (female)	0.785
Leukomonocytes	1.32 ± 0.62	1.06 ± 0.55	1.1-3.2 × 109/L	0.002
Platelets	197.63 ± 77.69	203.92 ± 92.59	125-350 × 109/L	0.611
CRP	1.79 ± 2.87	4.34 ± 4.41	0-0.6 mg/dL	< 0.001
Procalcitonin	0.05 ± 0.05	1.50 ± 6.77	< 0.1 ng/mL	0.078
	Coagulation parameters
PT	11.51 ± 1.55	11.94 ± 1.41	9-13 s	0.043
INR	1.00 ± 0.15	1.03 ± 0.13	0.7-1.3	0.132
PTA	102.41 ± 22.35	95.42 ± 21.74	70%-130%	0.029
Fibrinogen	2.72 ± 0.71	3.02 ± 0.76	2-4 g/L	0.006
Thrombin time	16.82 ± 3.26	17.99 ± 12.59	14-21 s	0.429
APTT	29.12 ± 5.66	29.11 ± 5.54	20-40 s	0.990
D-dimer	0.76 ± 1.16	2.45 ± 3.80	0-1 µg/mL	< 0.001

TBil: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: γ-glutamyl transpeptidase; ALP: Alkaline phosphatase; WBC: White blood cell count; CRP: C-reactive protein; PT: Prothrombin time; INR: International normalized ratio; PTA: Prothrombin activity; APTT: Activated partial thromboplastin time.