Prognostic value of pretreatment contrast-enhanced computed tomography in esophageal neuroendocrine carcinoma: A multi-center follow-up study

Table 4 Association of clinical factors and computed tomography characteristics

Variable	Adjuvant chemotherapy			Variable	Degree of enhancement				Variable	N stage
	Performed	None	P value		Mild	Moderate	Marked	P value		Absent	Present	P value
Gender			0.933	Gender				0.677	Gender			0.862
Male	46 (66)	7 (70)		Male	25 (71)	4 (36)	24 (77)		Male	21 (70)	32 (68)
Female	24 (34)	3 (30)		Female	10 (29)	7 (64)	7 (23)		Female	9 (30)	15 (32)
Age			0.299	Age				0.431	Age			0.769
< 64 yr	32 (48)	3 (30)		< 64 yr	18 (51)	4 (36)	13 (42)		< 64 yr	13 (43)	22 (47)
≥ 64 yr	35 (52)	7 (70)		≥ 64 yr	17 (49)	7 (64)	18 (58)		≥ 64 yr	17 (57)	25 (53)
Tumor length				Tumor length				0.352	Tumor length			0.018a
< 40 mm	37 (55)	4 (40)	0.375	< 40 mm	20 (57)	7 (64)	14 (45)		< 40 mm	21 (70)	20 (43)
≥ 40 mm	30 (45)	6 (60)		≥ 40 mm	15 (43)	4 (36)	17 (55)		≥ 40 mm	9 (30)	27 (57)
T stage			0.243	T stage				0.839	T stage			0.003a
cT1-2	27 (40)	6 (60)		cT1-2	15 (43)	5 (45)	13 (42)		cT1-2	19 (63)	14 (30)
cT3-4	40 (60)	4 (40)		cT3-4	20 (57)	6 (55)	18 (58)		cT3-4	11 (37)	33 (70)
N stage			0.942	N stage				0.942	M stage			< 0.001a
Absent	26 (39)	4 (40)		Absent	14 (47)	5 (45)	11 (35)		Absent	27 (90)	22 (47)
Present	41 (61)	6 (60)		Present	21 (45)	6 (55)	20 (65)		Present	3 (10)	25 (53)
M stage			0.132	M stage				0.255	Wall thickness			0.015a
Absent	40 (60)	9 (90)		Absent	25 (71)	6 (55)	18 (58)		< 11 mm	20 (67)	18 (38)
Present	27 (40)	1 (10)		Present	10 (29)	5 (45)	13 (42)		≥ 11 mm	10 (33)	29 (62)
Wall thickness			0.532	Wall thickness				0.029a	Surgery			0.203
< 11 mm	34 (61)	4 (40)		< 11 mm	20 (57)	9 (82)	9 (29)		Performed	9 (30)	21 (45)
≥ 11 mm	33 (39)	6 (60)		≥ 11 mm	15 (43)	2 (18)	22 (71)		None	21 (70)	26 (55)
Enhanced homogeneity			0.916	Enhanced homogeneity				0.122	Enhanced homogeneity			0.165
Homogeneous	6 (9)	1 (10)		Homogeneous	5 (14)	1 (9)	1 (3)		Homogeneous	1 (3)	6 (13)
Heterogeneous	61 (91)	9 (90)		Heterogeneous	30 (86)	10 (91)	30 (97)		Heterogeneous	29 (97)	41 (87)
Degree of enhancement			0.018a	Surgery				0.91	Degree of enhancement			0.726
Mild	12 (18)	0		Performed	21 (60)	7 (64)	19 (61)		Mild	5 (16)	6 (12)
Moderate	22 (33)	8 (80)		None	14 (40)	4 (36)	12 (39)		Moderate	11 (37)	20 (43)
Marked	33 (49)	2 (20)							Marked	14 (47)	21 (45)

^aStatistically significant.