Impact of interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer patients

Table 2 Surgical results and tumor outcomes

Variable	Interval ≤ 9 wk	Interval > 9 wk	P value
	(group A, n = 139)	(group B, n = 92)
Surgical procedure
Miles (n, %)	55 (39.6)	45 (48.9)	0.161
Dixon (n, %)	73 (52.5)	40 (43.5)	0.179
Hartmann (n, %)	11 (7.9)	7 (7.6)	0.933
Operative time (min, mean ± SD)	194.5 ± 65.2	222.2 ± 67.8	0.001
Estimated blood loss (mL, mean ± SD)	68.0 ± 92.1	100.9 ± 133.9	0.007
Postoperative complications	7 (5)	5 (5.4)	0.894
Hemorrhage, n (%)	1 (0.7)	1 (1.1)
Anastomotic leakage, n (%)	5 (3.6)	2 (2.2)
Ileus, n (%)	2 (1.4)	0 (0)
Reoperation, n (%)	3 (2.2)	1 (1.1)
Cardiovascular, n (%)	0 (0)	1 (1.1)
Urinary retention, n (%)	1 (0.7)	2 (2.2)
Exhaust, d (mean ± SD)	3.6 ± 1.5	3.9 ± 1.5	0.148
Defecation, d (mean ± SD)	4.7 ± 1.7	5.2 ± 2.0	0.249
Micturition, d (mean ± SD)	4.5 ± 1.4	4.4 ± 1.0	0.614
Degree of differentiation, n (%)			0.475
Low and low-moderate grades	22 (15.8)	10 (10.9)
Moderate, moderate-high, and high grades	114 (82)	79 (85.9)
Signet-ring and mucinous adenocarcinoma	3 (2.2)	3 (3.3)
ypT, n (%)			0.009
1	3 (2.2)	2 (2.2)
2	29 (20.9)	19 (20.7)
3	82 (59)	39 (42.4)
4	10 (7.2)	7 (7.6)
ypN, n (%)			0.014
0	68 (48.9)	60 (65.2)
1	50 (36)	24 (26.1)
2	21 (15.1)	8 (8.7)
pCR	15 (10.8)	25 (27.2)	0.001
Total lymph nodes	19.0 ± 8.8	15.7 ± 8.7	0.001
Positive lymph nodes	1.6 ± 3.2	0.8 ± 1.7	0.045

pCR: Pathologic complete response.