Efficacy of a Chinese herbal formula on hepatitis B e antigen-positive chronic hepatitis B patients

Table 7 Baseline variables and change in hepatitis B virus e antigen and hepatitis B surface antigen from week 12 to week 48 associated with HBeAg clearance

Variables	Univariable analysis			Multivariable analysis
	OR	95%CI	P	OR	95%CI	P
Sex	0.788	(0.367-1.986)	0.453
Age	0.947	(0.886-1.198)	0.715
HBV DNA	0.633	(0.574-1.393)	0.214
IFN-γ	0.915	(0.837-2.131)	0.656
IL-2	0.773	(0.512-1.318)	0.375
Baseline HBeAg	1.653	(1.332-2.257)	0.030	1.027	(1.145-1. 908)	0.047
Baseline HBsAg	2.431	(1.236-3.915)	0.004	1.339	(1.131-1.862)	0.009
Week 24 HBeAg change from baseline	2.762	(1.562-4.256)	< 0.001	2.338	(1.636-4.863)	< 0.001
Week 36 HBeAg change from baseline	3.411	(1.976-4.526)	< 0.001	3.185	(1.977-5.466)	< 0.001
Week 24 HBsAg change from baseline	4.458	(2.153-10.198)	< 0.001	3.273	(1.375-5.216)	< 0.001
Week 36 HBsAg change from baseline	5.371	(3.239-6.392)	< 0.001	5.788	(2.726-10.612)	< 0.001
Week 12 ALT elevation	2.676	(1.133-5.432)	0.016	2.049	(1.363-9.198)	0.006
Week 24 ALT elevation	3.373	(2.637-7.568)	0.003	3.788	(2.728-7.687)	0.003
Week 48 IFN-γ elevation	2.735	(1.317-6.682)	0.002	2.171	(1.163-2.961)	0.007
Week 48 IL-2 elevation	2.133	(1.171-8.616)	0.008	1.882	(1.026-2.613)	0.020

CI: Confidence interval; ALT: Alanine aminotransferase; HBV: Hepatitis B virus; HBsAg: Hepatitis B virus surface antigen; HBeAg: Hepatitis B virus e antigen; IL-2: Interleukin-2; IFN-γ: Interferon-γ.