Efficacy of a Chinese herbal formula on hepatitis B e antigen-positive chronic hepatitis B patients

doi:10.3748/wjg.v26.i30.4501

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Trials Study

World J Gastroenterol. Aug 14, 2020; 26(30): 4501-4522
Published online Aug 14, 2020. doi: 10.3748/wjg.v26.i30.4501

Table 4 Baseline characteristics of all study patients

Variable	Treatment (ICE) group (n = 199)	Control group(n = 196)	χ²/t/ Z	P value
Age (mean ± SD), yr	38.51 ± 7.63	38.90 ± 7.54	-0.904	0.366^a
Range	30-65	30-63
Sex, n (%)			0.013	0.910^b
Male	128 (64.3)	125 (63.8)
Female	71 (35.7)	71 (36.2)
Regions (N)			2.796	0.593^b
Eastern	30 (14.42)	28 (14.97)
Western	22 (10.58)	18 (9.63)
Southern	89 (42.79)	69 (36.90)
Northern	40 (19.23)	48 (25.67)
Central	27 (12.98)	24 (12.83)
Smoking			0.491	0.484^b
Yes	57 (28.64)	50 (25.51)
No	142 (71.36)	146 (74.49)
Alcohol consumption			3.626	0.057^b
Yes	18 (9.05)	30 (15.31)
No	181 (90.95)	166 (84.69)
Genotype			0.522	0.770^b
B	99 (49.75)	93 (47.45)
C	90 (45.23)	95 (48.47)
D	10 (5.02)	8 (4.08)
Genealogy of hepatocellular carcinoma	2 (1.00)	3 (1.53)	0.000	0.986^b
Clinical course (mean ± SD) week	90.21 ± 22.40	86.69 ± 27.20	-1.607	0.108^a
Liver function (mean ± SD)
ALT, IU/L	29.29 ± 8.19	30.12 ± 6.32	1.126	0.261^c
AST, IU/L	24.86 ± 7.53	25.79 ± 6.19	1.340	0.181^c
TB, μmol/L	14.34 ± 3.25	13.98 ± 4.15	0.961	0.337^c
HBV DNA baseline level, (%)			0.154	0.695^b
2 to < 5 log10 IU/mL	0 (0)	0 (0)
5 to < 7 log10 IU/mL	14 (2.01)	12 (1.02)
7to < 9 log10 IU/mL	185 (97.99)	184 (98.98)
HBsAg (mean ± SD), log10 IU/mL	3.86 ± 0.52	3.89 ± 0.42	-0.758	0.449^a
HBeAg (mean ± SD), SCO/mL	1138.18 ± 423.99	1158.40 ± 401.86	-0.393	0.695^a
HBeAb (mean ± SD), SCO/mL	38.43 ± 14.28	40.01 ± 12.15	-0.904	0.366^a
Histological scores
Knodell (HAI), n (%)	168 (84.40)	156 (79.60)	0.010	0.922^b
≥ 4	60 (35.71)	55(35.26)
< 4	108 (64.29)	101 (64.74)
Ishak (FIB), n (%)			0.035	0.851^b
≥ 2	67 (39.90)	60 (38.46)
< 2	101 (60.10)	96 (61.54)

^a: Mann-Whitney U test;

^b: Chi-square test;

^c: t-test. ICE: Invigorating kidney and clearing away the heat and expelling superficial evils; SD: Standard deviation; ALT: Alanine aminotransferase; AST: Aspartate transaminase; TB: Total bilirubin; HBV: Hepatitis B virus; HBsAg: Hepatitis B virus surface antigen; HBeAg: Hepatitis B virus e antigen; HBeAb: Hepatitis B virus e antibody.

Citation: Xing YF, Wei CS, Zhou TR, Huang DP, Zhong WC, Chen B, Jin H, Hu XY, Yang ZY, He Q, Jiang KP, Jiang JM, Hu ZB, Deng X, Yang F, Li FY, Zhao G, Wang LC, Mi YQ, Gong ZJ, Guo P, Wu JH, Shi WQ, Yang HZ, Zhou DQ, Tong GD. Efficacy of a Chinese herbal formula on hepatitis B e antigen-positive chronic hepatitis B patients. World J Gastroenterol 2020; 26(30): 4501-4522
URL: https://www.wjgnet.com/1007-9327/full/v26/i30/4501.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i30.4501