Efficacy and safety of lenvatinib for patients with advanced hepatocellular carcinoma: A retrospective, real-world study conducted in China

doi:10.3748/wjg.v26.i30.4465

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2020; 26(30): 4465-4478
Published online Aug 14, 2020. doi: 10.3748/wjg.v26.i30.4465

Table 5 Multivariate analysis of the objective response rate and progression-free survival in patients with advanced hepatocellular carcinoma treated with lenvatinib

Clinical factors	Category	Analysis of ORR		Analysis of PFS
Clinical factors	Category	P value	OR, 95%CI	P value	HR, 95%CI
Age (yr)	< 58.8	0.489	0.978 (0.919-1.041)	0.010	0.959 (0.929-0.990)
Gender	Male	0.571	1.828 (0.227-14.724)	0.606	1.137 (0.698-1.850)
HBV infection	HBV	0.371	2.300 (0.370-14.290)	0.151	1.844 (0.799-4.257)
First-line therapy	Sorafenib	0.212	0.324 (0.055-1.901)	0.167	1.724 (0.796-3.734)
Extrahepatic spread	Without	0.604	0.600 (0.088-4.118)	0.443	0.675 (0.247-1.844)
Tumor occupation	< 50%	0.937	1.080 (0.162-7.178)	0.169	2.043 (0.738-5.654)
Portal vein thrombus	Without	0.987	0.985 (0.167-5.817)	0.037	0.381 (0.154-0.944)
History of TACE	With	0.396	2.229 (0.350-14.186)	0.776	0.875 (0.348-2.197)
Combination factors
ECOG-PS score	0	0.066	3.571 (0.876-14.564)	0.05	4.9 (0.998-24.193)
ALBI stage	1	0.651	-	0.462	0.574 (0.130-2.524)
Child-Pugh class	A	0.061	-	0.042	0.468 (0.225-0.973)
BCLC stage	B	0.487	1.593 (0.425-5.971)	0.031	0.465 (0.232-0.931)

ECOG: Eastern Cooperative Oncology Group; PS: Performance Status; ALBI grade: Albumin-bilirubin grade; BCLC: Barcelona Clinic Liver Cancer; TACE: Transarterial chemoembolization; HBV: Hepatitis B virus; HCV: Hepatitis C virus; EHS: Extrahepatic spread; ORR: Objective response rate; PFS: Progression-free survival; OR: Odds ratio; HR: Hazard ratio.

Citation: Wang DX, Yang X, Lin JZ, Bai Y, Long JY, Yang XB, Seery S, Zhao HT. Efficacy and safety of lenvatinib for patients with advanced hepatocellular carcinoma: A retrospective, real-world study conducted in China. World J Gastroenterol 2020; 26(30): 4465-4478
URL: https://www.wjgnet.com/1007-9327/full/v26/i30/4465.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i30.4465