Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford

doi:10.3748/wjg.v26.i30.4428

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Aug 14, 2020; 26(30): 4428-4441
Published online Aug 14, 2020. doi: 10.3748/wjg.v26.i30.4428

Table 3 Remission at 6 mo and 12 mo of vedolizumab therapy

	Total	Australia	Oxford	P value
Remission at 6 mo, n (%)	147 (62)	110/173(64)	37/65 (57)	0.34
Remission at 12 mo, n (%)	120/201 (60)	87/138 (63)	33/65 (52)	0.09
	Total	Anti-TNF naive	Anti-TNF exposed
Remission at 6 mo, n (%)	147/238 (62)	103/142 (73)	44/96 (46)	< 0.001
Remission at 12 mo, n (%)	120/201 (60)	76/115 (66)	44/86 (51)	0.03
	Anti-TNF exposed	Primary LOR	Secondary LOR
Remission at 6 mo, n (%)	44/96 (46)	16/42 (38)	28/54 (52)	0.18
Remission at 12 mo, n (%)	44/86 (51)	17/38 (44)	27/48 (56)	0.28

VDZ: Vedolizumab; TNF: Tumor necrosis factor; Primary LOR: Primary loss of response to anti-TNF agent; Secondary LOR: Secondary loss of response to anti-TNF agent.

Citation: Pulusu SSR, Srinivasan A, Krishnaprasad K, Cheng D, Begun J, Keung C, Van Langenberg D, Thin L, Mogilevski T, De Cruz P, Radford-Smith G, Flanagan E, Bell S, Kashkooli S, Sparrow M, Ghaly S, Bampton P, Sawyer E, Connor S, Rizvi QUA, Andrews JM, Mahy G, Chivers P, Travis S, Lawrance IC. Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford. World J Gastroenterol 2020; 26(30): 4428-4441
URL: https://www.wjgnet.com/1007-9327/full/v26/i30/4428.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i30.4428