Programmed cell death-1 inhibitor-related sclerosing cholangitis: A systematic review

Table 2 Baseline characteristics of cases of programmed cell death-1 inhibitor-related sclerosing cholangitis

Case	Ref.	Age	Sex	Primary disease	Drug	Cycles until onset	Symptoms
1	Gelsomino et al[21]	79	M	NSCLC	Nivolumab	4	Itching, jaundice
2	Kawakami et al[19]	64	M	NSCLC	Nivolumab	9	Fever, abdominal discomfort
3	Kawakami et al[19]	73	F	NSCLC	Nivolumab	6	Fever, vomiting, abdominal discomfort, diarrhea
4	Kawakami et al[19]	82	F	NSCLC	Nivolumab	12	Fever, general fatigue
5	Kashima et al[22]	63	M	NSCLC	Nivolumab	24	Epigastric pain, soft stool
6	Doherty et al[23]	49	F	Melanoma	Pembrolizumab	1	Jaundice
7	Doherty et al[23]	59	F	Melanoma	Nivolumab	3	None (liver dysfunction)
8	Doherty et al[23]	76	M	epithelioid mesothelioma	Pembrolizumab	1	Jaundice
9	Cho et al[24]	69	M	NSCLC	Avelumab	21	Right upper abdominal discomfort
10	Hamoir et al[25]	71	M	NSCLC	Nivolumab	NA (11 mo)	None (liver dysfunction)
11	Kuraoka et al[26]	69	M	NSCLC	Nivolumab	3	Pruritic rash, liver dysfunction
12	Ogawa et al[27]	73	M	Melanoma	Pembrolizumab	NA (3 mo)	None (liver dysfunction)
13	Kono et al[28]	69	F	GC	Nivolumab	2	Jaundice
14	Noda-Narita et al[29]	57	F	NSCLC	Nivolumab	NA (12 mo)	Abdominal pain
15	Sawada et al[30]	76	M	GC	Nivolumab	4	None (liver dysfunction)
16	Tallec et al[31]	56	F	NSCLC	Nivolumab	16 (9 mo)	Myalgia, skin thickening
17	Oda et al[32]	43	M	GC	Nivolumab	1	Fever, tachycardia, appetite loss, malaise
18	Koya et al[33]	66	M	SCLC	Pembrolizumab	5	Epigastric pain
19	Fouchard et al[34]	52	M	NSCLC	Nivolumab	8	Abdominal pain
20	Fouchard et al[34]	NA	M	NSCLC	Durvalumab (+ tremelimumab)	4	Fever, abdominal pain
21	Fouchard et al[34]	61	M	NSCLC	Pembrolizumab	17	None (liver dysfunction)
22	Cǎlugǎreanu et al[35]	43	F	Melanoma	Nivolumab	27	Epigastralgia, anorexia,
23	Anderson et al[36]	67	M	NSCLC	Nivolumab	8	Right upper abdominal pain
24	Zen et al[37]	68	M	NSCLC	Pembrolizumab	NA (5.5 mo)	Abdominal pain, vomiting
25	Zen et al[40]	67	M	NSCLC	Pembrolizumab	NA (1 mo)	Fever, malaise
26	Our case	61	M	BC	Pembrolizumab	5	Fever
27	Our case	89	M	BC	Pembrolizumab	4	None (liver dysfunction)
28	Our case	63	M	NSCLC	Pembrolizumab	7	None (liver dysfunction)
29	Our case	55	M	NSCLC	Nivolumab	11	Abdominal pain
30	Our case	81	F	NSCLC	Nivolumab	25	Backache
31	Our case	82	F	NSCLC	Nivolumab	2	None (liver dysfunction)

NSCLC: Non-small cell lung cancer; SCLC: Small cell lung cancer; GC: Gastric cancer; BC: Bladder cancer; NA: Not available.