Metabolite profile comparisons between ascending and descending colon tissue in healthy adults

Table 3 Colon lipid metabolites with fold-differences by colon location and body mass index

Sub pathway	Biochemical name	Fold difference ascending/descending
		NW	P value	OW	P value	OB	P value
Long chain fatty acids	Palmitate (16:0)	1.3	0.02	1.0	0.75	0.7	0.04
		5	1	4	4	3	4
	Margarate (17:0)	1.2	0.13	0.8	0.33	0.7	0.03
		1	1	8		1	7
	Stearate (18:0)	1.3	0.01	0.9	0.61	0.6	0.01
		9	3	4	5	8	6
	Oleate/vaccenate (18:1)	1.5	0.04	1.2	0.36	0.9	0.80
			8		5	4	0
	Nonadecanoate (19:0)	1.1	0.29	0.8	0.26	0.6	0.01
		2		8	5	9	1
	Arachidate (20:0)	1.3	0.02	0.9	0.56	0.6	0.02
		5	5	3	4	9	5
	Eicosenoate (20:1)	1.4	0.04	1.1	0.56	1.0	0.88
		8	1	1	2	3	3
	Erucate (22:1n9)	1.5	0.03	1.0	0.81	1.1	0.47
		2	1	4	1	8	2
Polyunsaturated fatty acid	Dihomo-linolenate (20:3n3 or n6)	1.5	0.04	1.2	0.28	1.1	0.56
		9	1	6	5	6	7
	Dihomo-linoleate (20:2n6)	1.6	0.01	1.1	0.41	1.2	0.46
		8	7	8	7		3
Fatty acid, dicarboxylate	Dodecadienoate (12:2)1	0.9	0.64	0.8	0.26	0.7	0.03
		5	5	7	1	1	2
Ketone bodies	3-hydroxybutyrate (BHBA)	0.4	0.00	0.9	0.90	1.0	0.82
		8	5	7	4	7	5
Fatty acid, metabolism (Acyl choline)	Linoleoylcholine1	1.2	0.34	1.1	0.62	2.0	0.02
		6	4	3		6	1
Fatty acid, monohydroxy	2-hydroxystearate	1.3	0.04	0.9	0.67	0.7	0.13
			2	5	7	9	5
Eicosanoid	15-HETE	1.6	0.04	1.1	0.51	1.9	0.03
		9	5	8	5	3	9
Endocannabinoid	Oleoyl ethanolamide	1.6	0.03	2.2	0.79	1.5	0.10
			8	3		5	9
	Palmitoyl ethanolamide	1.3	0.02	1.0	0.56	1.1	0.42
		7	4	8	1	4	1
	Linoleoyl ethanolamide	2.1	0.00	1.2	0.35	1.5	0.17
		1	5	6	1	2	1
Phosphatidylethanolamine	1-stearoyl-2-oleoyl-GPE (18:0/18:1)	0.8	0.28	0.6	0.01	0.7	0.15
		1	4		6		6
	1-stearoyl-2-linoleoyl-GPE (18:0/18:2)1	0.9	0.87	0.6	0.04	0.6	0.09
		7	5	5	3	5	7
	1,2-dioleoyl-GPE (18:1/18:1)	0.6	0.07	0.6	0.03	0.7	0.19
		9		5	8	3
	1-oleoyl-2-docosahexaenoyl-GPE (18:1/22:6)1	0.6	0.01	0.7	0.08	0.4	0.00
		2		3	1	3	1
Lysophospholipid	1-palmitoleoyl-GPC (16:1)1	1.5	0.03	1.3	0.20	1.2	0.33
		9	6	1	2	8	3
	1-linoleoyl-GPC (18:2)	1.6	0.00	1.5	0.01	1.4	0.08
			8	7	1	3	5
	1-arachidonoyl-GPC (20:4n6)1	1.74	0.035	1.55	0.092	1.39	0.285
	1-linoleoyl-GPS (18:2)1	1.8	0.00	1.4	0.07	1.2	0.31
		9	2	1	7	6	4
	1-palmitoyl-GPG (16:0)1	2.1	0.00	1.3	0.18	0.8	0.51
		1	5	8	3	3	5
	1-stearoyl-GPG (18:0)	2.1	0.00	1.3	0.16	0.8	0.66
		6	2	6		9	5
	1-oleoyl-GPG (18:1)1	1.6	0.01	1.0	0.66	1.1	0.47
				7	8	6	6
	1-palmitoyl-GPI (16:0)	1.5	0.04	1.1	0.55	0.7	0.31
		8	1	3	4	7	8
	1-stearoyl-GPI (18:0)	1.4	0.03	1.0	0.66	0.8	0.50
		9	4	8	3	7	7
	1-oleoyl-GPI (18:1)	1.6	0.02	1.2	0.24	0.9	0.81
		4	7	8	7	4	8
	1-linoleoyl-GPI (18:2)1	1.4	0.01	1.1	0.48	1.2	0.22
		8	7	1	8	6	5
Plasmalogen	1-(1-enyl-palmitoyl)-2-oleoyl-GPE (P-16:0/18:1)1	0.7	0.08	0.6	0.02	0.6	0.13
		1	9	2	2	9	8
	1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1)1	0.7	0.10	0.6	0.01	0.7	0.16
		4	5	3	9	3
	1-(1-enyl-stearoyl)-2-oleoyl-GPE (P-18:0/18:1)	0.7	0.23	0.6	0.03	0.7	0.31
		9	4	4	3	8	1
Monoacylglycerol	1-palmitoylglycerol (16:0)	1.3	0.25	2.6	0.00	1.2	0.53
		5	3	1	1	2	7
	1-palmitoleoylglycerol (16:1)1	1.6	0.09	2.2	0.00	1.1	0.62
			2	3	7	8	3
	1-oleoylglycerol (18:1)	1.6	0.20	2.2	0.03	0.7	0.50
			5	5	6	4	7
	1-linolenoylglycerol (18:3)	1.5	0.07	2.0	0.00	1.0	0.82
		4	4	7	5	7	3
	1-dihomo-linolenylglycerol (20:3)	1.5	0.25	2.2	0.04	0.7	0.57
		5	1	6		7	4
	1-arachidonylglycerol (20:4)	1.5	0.21	2.3	0.01	1.1	0.78
		1	8	4	7	2	3
	2-palmitoleoylglycerol (16:1)1	1.3	0.25	1.7	0.03	0.9	0.89
		4	7	7	4	6	8
	2-arachidonoylglycerol (20:4)	1.3	0.25	1.6	0.03	0.9	0.75
		1	3	8	5	1	2
Diacylglycerol	Linoleoyl-linolenoyl-glycerol (18:2/18:3) (2)1	1.3	0.51	1.6	0.29	3.3	0.03
		4	7	1	6	2	9
Ceramides	N-palmitoyl-sphingosine (d18:1/16:0)	0.9	0.73	0.6	0.00	0.7	0.04
		6	1	9	8	3	9
	N-stearoyl-sphingosine (d18:1/18:0)1	1.0	0.57	0.7	0.03	0.8	0.33
		9	8		1	3	9
	N-palmitoyl-heptadecasphingosine (d17:1/16:0)1	0.9	0.95	0.7	0.04	0.8	0.20
		9	7	4	2		0
Hexosylceramides (HCER)	Glycosyl-N-palmitoyl-sphingosine (d18:1/16:0)	0.7	0.04	0.6	0.00	0.6	0.02
		4	8	2	3	7	9
Primary bile acid	Glycochenodeoxycholate	0.9	0.75	1.8	0.00	0.8	0.54
			8	6	3	7	0
	Taurochenodeoxycholate	1.0	0.98	1.6	0.45	0.8	1
		4	7	2	6	6
Secondary bile acid	Glycolithocholate sulfate	0.9	0.70	1.4	0.01	1	1
		5	3		2
	Deoxycholate	0.9	0.79	0.6	0.12	0.7	0.00
			7	8	3	3	9

¹Not officially confirmed, but confident. Values presented are fold-difference of the mean relative abundance between ascending/descending colon, by weight class. Bold indicates P value < 0.05. BMI: Body mass index; NW: Normal weight; OW: Overweight; OB: Obese.