Metabolite profile comparisons between ascending and descending colon tissue in healthy adults

Table 2 Fold-differences of colon and stool metabolites

Sub pathway	Biochemical name	Fold difference colon ascending/descending						Fold difference stool BMI comparisons
		NW	P value	OW	P value	OB	P value	Ow NW	P value	OB NW	P value	OB OW	P value
Methione, Cysteine, SAM and taurine metabolism	N-acetylglut-amine	1.47	0.027	1.15	0.412	1.13	0.534	1.20	0.711	3.44	0.029	0.35	0.096
Endocannabinoid	Oleoyl ethanolamide	1.6	0.038	1.06	0.790	1.55	0.109	0.23	0.261	1.94	0.174	0.12	0.026
	Linoleoyl ethanolamide	2.11	0.005	1.26	0.351	1.52	0.171	0.21	0.172	2.49	0.146	0.08	0.012
Phospholipid metabolism	Trimethylamine N-oxide	0.92	0.832	1.02	0.969	2.8	0.049	1.47	0.494	6.23	0.025	0.24	0.149
Phosphatidylethanolamine	1-palmitoyl-2-oleoyl-GPE (16:0/18:1)	0.77	0.145	0.66	0.029	0.7	0.113	2.63	0.044	2.57	0.244	1.02	0.322
Lysophospholipid	2-palmitoyl-GPC (16:0)1	1.52	0.019	1.18	0.317	0.93	0.709	0.84	0.667	2.81	0.061	0.30	0.039
	1-linoleoyl-GPG (18:2)1	1.55	0.030	1.26	0.239	1.05	0.819	1.25	0.335	3.45	0.001	0.36	0.010
Primary bile acid metabolism	Cholate	1.12	0.612	0.84	0.447	0.55	0.041	3.13	0.512	61.06	0.019	0.05	0.114
	Chenodeoxycholate	2.89	0.049	0.41	0.094	0.9	0.872	0.76	0.697	21.80	0.005	0.03	0.004
Secondary bile acid metabolism	Taurodeoxycholate	1.13	0.482	1.49	0.027	0.78	0.249	0.43	0.434	9.32	0.080	0.05	0.024
Pyrimidine metabolism, cytidine containing	Cytidine	1.93	0.036	1.46	0.216	1.12	0.748	1.25	0.469	2.06	0.047	0.61	0.249

¹Not officially confirmed, but confident. Values presented are fold-change of the mean relative abundance within ascending verses descending colon tissue and BMI comparisons from stool. Bold indicates P value < 0.05. NW: Normal weight; OW: overweight; OB: Obese; BMI: Body mass index.