Nucleotide excision repair pathway gene polymorphisms are associated with risk and prognosis of colorectal cancer

Table 6 Association between nucleotide excision repair polymorphisms and colorectal cancer prognosis

SNP genotype	CRC patients	Death	MST (M)	Univariate		Multivariate
				P value	HR (95%CI)	P value	HR (95%CI)
DDB2
rs2029298	n = 560	n = 94
GG	262	50	44.41		1(Ref)		1 (Ref)
GA	230	35	47.41	0.368	0.82 (0.53-1.26)	0.393	0.82 (0.53-1.29)
AA	68	9	48.61	0.265	0.67 (0.33-1.36)	0.467	0.77 (0.37-1.57)
GA + AA vs GG				0.235	0.78 (0.52-1.17)	0.307	0.81 (0.53-1.22)
AA vs GA + GG				0.370	0.73 (0.37-1.45)	0.581	0.82 (0.41-1.65)
ERCC1
rs11615	n = 561	n = 95
CC	345	62	46.41		1 (Ref)		1 (Ref)
CT	188	29	47.21	0.647	0.90 (0.58-1.40)	0.947	1.02 (0.65-1.59)
TT	28	4	45.81	0.955	0.97 (0.35-2.67)	0.975	0.98 (0.35-2.76)
CT + TT vs CC				0.662	0.91 (0.60-1.39)	0.974	0.99 (0.65-1.53)
TT vs CT + CC				0.999	1.00 (0.37-2.73)	0.911	0.94 (0.34-2.60)
rs735482	n = 552	n = 91
CC	123	23	46.81		1 (Ref)		1 (Ref)
CA	258	38	47.31	0.982	0.99 (0.59-1.67)	0.582	1.16 (0.69-1.96)
AA	171	30	45.51	0.603	1.16 (0.67-1.99)	0.774	0.92 (0.53-1.61)
CA + AA vs CC				0.829	1.05 (0.66-1.69)	0.923	1.02 (0.64-1.65)
AA vs CA + CC				0.517	1.16 (0.75-1.79)	0.521	0.86 (0.55-1.35)
ERCC2
rs1052555	n = 563	n = 95
CC	506	86	46.61		1 (Ref)		1 (Ref)
CT	56	8	48.31	0.377	0.72 (0.35-1.49)	0.998	1.00 (0.48-2.09)
TT	1	1	2	< 0.001	49.73 (6.37-388.47)	0.010	14.99 (1.90-118.10)
CT + TT vs CC				0.551	0.81 (0.41-1.61)	0.744	1.12 (0.56-2.26)
TT vs CT + CC				< 0.001	55.22 (7.07-431.35)	0.009	15.89 (2.02-125.16)
rs50871	n = 551	n = 92
TT	294	43	47.01		1 (Ref)		1 (Ref)
TG	210	40	45.71	0.256	1.28 (0.83-1.98)	0.446	1.19 (0.77-1.84)
GG	47	9	45.81	0.541	1.25 (0.61-2.57)	0.576	0.80 (0.37-1.74)
TG + GG vs TT				0.239	1.28 (0.85-1.93)	0.646	1.10 (0.73-1.68)
GG vs TG + TT				0.749	1.12 (0.56-2.23)	0.354	0.71 (0.34-1.47)
ERCC5
rs1047768	n = 553	n = 92
CC	55	9	46.71		1 (Ref)		1 (Ref)
CT	233	44	46.51	0.785	1.11 (0.54-2.26)	0.945	0.97 (0.45-2.09)
TT	265	39	47.01	0.933	1.03 (0.50-2.13)	0.542	0.78 (0.36-1.72)
CT + TT vs CC				0.851	1.07 (0.54-2.13)	0.768	0.90 (0.43-1.87)
TT vs CT + CC				0.799	0.95 (0.63-1.43)	0.387	0.83 (0.54-1.27)
rs2094258	n = 555	n = 93
GG	207	38	46.61		1 (Ref)		1 (Ref)
GA	269	42	47.01	0.721	0.92 (0.60-1.43)	0.400	0.82 (0.53-1.29)
AA	79	13	44.31	0.973	0.99 (0.53-1.86)	0.588	0.84 (0.44-1.59)
GA + AA vs GG				0.773	0.94 (0.62-1.42)	0.424	0.84 (0.55-1.29)
AA vs GA + GG				0.869	1.05 (0.59-1.89)	0.916	1.03 (0.57-1.87)
rs2228959	n = 558	n = 93
CC	501	82	47.11		1 (Ref)		1 (Ref)
CA	53	9	45.41	0.768	1.11 (0.56-2.21)	0.811	0.92 (0.46-1.85)
AA	4	2	13.81	0.006	7.18 (1.75-29.50)	0.046	4.32 (1.03-18.17)
CA + AA vs CC				0.402	1.31 (0.70-2.46)	0.847	1.07 (0.56-2.02)
AA vs CA + CC				0.006	7.16 (1.75-29.32)	0.049	4.20 (1.00-17.60)
rs2296147	n = 556	n = 92
TT	318	46	47.41		1 (Ref)		1 (Ref)
TC	207	42	45.41	0.384	1.21 (0.79-1.83)	0.194	1.32 (0.87-2.02)
CC	31	4	48.11	0.691	0.81 (0.29-2.26)	0.658	1.32 (0.38-4.57)
TC + CC vs TT				0.484	1.16 (0.77-1.74)	0.184	1.33 (0.87-2.02)
CC vs TC + TT				0.573	0.75 (0.28-2.04)	0.978	1.02 (0.31-3.32)
rs873601	n = 558	n = 95
GG	140	21	47.51		1 (Ref)		1 (Ref)
GA	301	49	46.91	0.745	1.09 (0.65-1.82)	0.923	0.98 (0.58-1.64)
AA	117	25	44.51	0.293	1.37 (0.76-2.44)	0.713	1.12 (0.62-2.03)
GA + AA vs GG				0.526	1.17 (0.72-1.90)	0.951	1.02 (0.62-1.66)
AA vs GA + GG				0.275	1.29 (0.82-2.04)	0.473	1.19 (0.74-1.90)
XPA
rs10817938	n = 545	n = 93
TT	351	61	46.61		1 (Ref)		1 (Ref)
TC	163	29	46.21	0.815	1.05 (0.68-1.64)	0.472	1.18 (0.75-1.88)
CC	31	3	49.51	0.429	0.63 (0.20-2.00)	0.903	0.93 (0.29-3.02)
TC + CC vs TT				0.968	0.99 (0.65-1.52)	0.489	1.17 (0.75-1.83)
CC vs TC+TT				0.414	0.62 (0.20-1.96)	0.863	0.90 (0.28-2.89)
rs3176629	n = 558	n = 94
CC	450	74	47.01		1 (Ref)		1 (Ref)
CT	103	19	44.81	0.470	1.20 (0.73-1.99)	0.420	0.81 (0.48-1.36)
TT	5	1	49.31	0.824	0.80 (0.11-5.76)	0.660	0.64 (0.09-4.64)
CT + TT vs CC				0.521	1.18 (0.72-1.93)	0.375	0.79 (0.47-1.33)
TT vs CT + CC				0.787	0.76 (0.11-5.47)	0.690	0.67 (0.09-4.82)
XPC
rs2607775	n = 556	n = 92
CC	494	84	46.81		1 (Ref)		1 (Ref)
CG	57	8	46.31	0.739	0.88 (0.43-1.83)	0.842	0.93 (0.44-1.94)
GG	5	0	NA	0.525	NA	0.969	NA
CG + GG vs CC				0.555	0.80 (0.39-1.66)	0.604	0.82 (0.40-1.72)
GG vs CG + CC				0.528	NA	0.970	NA

SNP: Single nucleotide polymorphism; CRC: Colorectal cancer; MST (M): Median survival time (mo); HR: Hazard ratio; CI: Confidence interval; NA: Not available.

¹mean survival time was provided when MST could not be calculated. Statistically significant associations are in bold (P < 0.05).