Nucleotide excision repair pathway gene polymorphisms are associated with risk and prognosis of colorectal cancer

Table 4 Effect of interaction between nucleotide excision repair polymorphisms and environmental factors on colorectal cancer risk¹

SNP genotype	Smoking		Drinking		Helicobacter pylori infection
	No	Yes	No	Yes	Negative	Positive
DDB2
rs2029298	n = 981	n = 468	n = 1190	n = 257	n = 810	n = 443
GA + AA
Case/Control	312/220	142/104	367/274	87/49	164/286	189/44
OR (95%CI)	1 (Ref)	0.96 (0.71-1.31)	1 (Ref)	1.33 (0.90-1.95)	1 (Ref)	7.49 (5.12-10.96)
GG
Case/Control	267/182	124/98	330/219	61/60	140/220	158/52
OR (95%CI)	1.03 (0.80-1.34)	0.89 (0.65-1.22)	1.13 (0.89-1.42)	0.76 (0.51-1.12)	1.11 (0.83-1.48)	5.30 (3.67-7.65)
	Pinteraction = 0.618		Pinteraction = 0.019 OR (95%CI) = 0.52 (0.30-0.90)		Pinteraction = 0.095
ERCC1
rs11615	n = 982	n = 467	n = 1190	n = 257	n = 812	n = 444
CT + TT
Case/Control	231/160	101/88	278/205	54/40	110/210	146/42
OR (95%CI)	1 (Ref)	0.80 (0.56-1.13)	1 (Ref)	1.00 (0.64-1.56)	1 (Ref)	6.64 (4.39-10.04)
CC
Case/Control	349/242	165/113	421/286	93/70	194/298	203/53
OR (95%CI)	1.00 (0.77-1.30)	1.01 (0.74-1.38)	1.09 (0.86-1.37)	0.98 (0.68-1.40)	1.24 (0.93-1.67)	7.31 (5.00-10.70)
	Pinteraction = 0.309		Pinteraction = 0.749		Pinteraction = 0.642
rs735482	n = 968	n = 461	n = 1171	n = 256	n = 803	n = 434
AA
Case/Control	175/124	87/64	213/148	49/40	89/161	115/24
OR (95%CI)	1 (Ref)	0.96 (0.65-1.43)	1 (Ref)	0.85 (0.53-1.36)	1 (Ref)	8.67 (5.20-14.44)
CA + CC
Case/Control	396/273	174/136	471/339	99/68	212/341	224/71
OR (95%CI)	1.03 (0.78-1.36)	0.91 (0.66-1.25)	0.97 (0.75-1.24)	1.01 (0.70-1.47)	1.13 (0.82-1.53)	5.71 (3.94-8.28)
	Pinteraction = 0.638		Pinteraction = 0.446		Pinteraction = 0.082
ERCC2
rs1052555	n = 986	n = 468	n = 1193	n = 259	n = 811	n = 447
CT + TT
Case/Control	55/39	30/27	68/56	17/10	27/54	39/11
OR (95%CI)	1 (Ref)	0.79 (0.41-1.53)	1 (Ref)	1.40 (0.59-3.30)	1 (Ref)	7.09 (3.15-15.99)
CC
Case/Control	527/365	236/175	632/437	131/101	277/453	312/85
OR (95%CI)	1.02 (0.67-1.58)	0.96 (0.61-1.51)	1.19 (0.82-1.73)	1.07 (0.69-1.66)	1.22 (0.75-1.99)	7.34 (4.36-12.35)
	Pinteraction = 0.624		Pinteraction = 0.319		Pinteraction = 0.712
ERCC5
rs1047768	n = 973	n = 464	n = 1177	n = 258	n = 808	n = 437
CT + TT
Case/Control	524/368	236/190	622/452	138/103	272/460	317/88
OR (95%CI)	1 (Ref)	0.87 (0.69-1.10)	1 (Ref)	0.97 (0.73-1.29)	1 (Ref)	6.09 (4.61-8.06)
CC
Case/Control	49/32	26/12	66/37	9/8	29/47	26/6
OR (95%CI)	1.08 (0.68-1.71)	1.52 (0.76-3.06)	1.30 (0.85-1.97)	0.82 (0.31-2.14)	1.04 (0.64-1.70)	7.33 (2.98-18.03)
	Pinteraction = 0.241		Pinteraction = 0.491		Pinteraction = 0.843
rs2094258	n = 973	n = 464	n = 1180	n = 255	n = 805	n = 443
GG
Case/Control	209/150	97/70	251/180	55/40	119/203	116/38
OR (95%CI)	1 (Ref)	1.00 (0.69-1.44)	1 (Ref)	0.99 (0.63-1.55)	1 (Ref)	5.21 (3.39-8.01)
GA + AA
Case/Control	364/250	169/128	442/307	91/69	181/302	233/56
OR (95%CI)	1.05 (0.80-1.36)	0.95 (0.69-1.29)	1.03 (0.81-1.31)	0.95 (0.66-1.37)	1.02 (0.76-1.37)	7.10 (4.91-10.27)
	Pinteraction = 0.587		Pinteraction = 0.685		Pinteraction = 0.314
rs2296147	n = 979	n = 466	n = 1185	n = 258	n = 807	n = 440
TT
Case/Control	356/251	151/126	426/301	81/75	184/298	207/59
OR (95%CI)	1 (Ref)	0.85 (0.64-1.13)	1 (Ref)	0.76 (0.54-1.08)	1 (Ref)	5.68 (4.03-8.01)
TC+CC
Case/Control	221/151	112/77	268/190	65/37	118/207	138/36
OR (95%CI)	1.03 (0.79-1.34)	1.03 (0.74-1.43)	1.00 (0.79-1.26)	1.24 (0.81-1.91)	0.92 (0.69-1.24)	6.21 (4.12-9.36)
	Pinteraction = 0.506		Pinteraction = 0.089		Pinteraction = 0.562
rs873601	n = 974	n = 462	n = 1179	n = 255	n = 798	n = 439
AA
Case/Control	130/94	47/51	148/116	29/28	69/126	75/25
OR (95%CI)	1 (Ref)	0.67 (0.41-1.07)	1 (Ref)	0.81 (0.46-1.44)	1 (Ref)	5.48 (3.19-9.40)
GA + GG
Case/Control	446/304	215/149	543/372	118/80	234/369	269/70
OR (95%CI)	1.06 (0.78-1.44)	1.04 (0.74-1.46)	1.14 (0.87-1.51)	1.16 (0.80-1.68)	1.16 (0.83-1.62)	7.02 (4.73-10.41)
	Pinteraction = 0.202		Pinteraction = 0.550		Pinteraction = 0.764
XPA
rs10817938	n = 952	n = 453	n = 1152	n = 252	n = 785	n = 429
TC + TT
Case/Control	527/380	239/183	631/459	135/103	281/470	311/88
OR (95%CI)	1 (Ref)	0.94 (0.75-1.19)	1 (Ref)	0.95 (0.72-1.27)	1 (Ref)	5.91 (4.47-7.81)
CC
Case/Control	33/12	20/11	45/17	8/6	14/20	25/5
OR (95%CI)	1.98 (1.01-3.89)	1.31 (0.62-2.77)	1.93 (1.09-3.41)	0.97 (0.33-2.81)	1.17 (0.58-2.36)	8.36 (3.17-22.09)
	Pinteraction = 0.516		Pinteraction = 0.299		Pinteraction = 0.738
XPC
rs2607775	n = 979	n = 463	n = 1184	n = 256	n = 809	n = 439
CC
Case/Control	513/369	238/195	617/458	134/103	273/475	314/88
OR (95%CI)	1 (Ref)	0.88 (0.70-1.11)	1 (Ref)	0.97 (0.73-1.28)	1 (Ref)	6.21 (4.70-8.21)
CG + GG
Case/Control	61/36	24/6	73/36	12/7	28/33	30/7
OR (95%CI)	1.22 (0.79-1.88)	2.88 (1.16-7.11)	1.51 (0.99-2.28)	1.27 (0.50-3.26)	1.48 (0.87-2.50)	7.46 (3.23-17.21)
	Pinteraction=0.066		Pinteraction=0.728		Pinteraction=0.766

¹P for interaction was adjusted by gender and age. Statistically significant associations are in bold (P < 0.05). SNP: Single nucleotide polymorphism; CRC: Colorectal cancer; CON: Control; OR: Odds ratio; CI: Confidence interval.