Nucleotide excision repair pathway gene polymorphisms are associated with risk and prognosis of colorectal cancer

doi:10.3748/wjg.v26.i3.307

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2020; 26(3): 307-323
Published online Jan 21, 2020. doi: 10.3748/wjg.v26.i3.307

Table 3 Cumulative effect of nucleotide excision repair polymorphisms associated with colorectal cancer risk¹, n (%)

Number of SNP risk genotypes	CRC	CON	P value	OR (95%CI)
Number of SNP risk genotypes	CRC	CON	P value	OR (95%CI)
	n = 841	n = 847
0	706 (83.9)	755 (89.1)		1 (Ref)
1	131 (15.6)	92 (10.9)	0.004	1.53 (1.15-2.04)
2	4 (0.5)	0 (0.0)	NA	NA
			P_trend = 0.001

¹P was adjusted by gender and age. Statistically significant associations are in bold (P < 0.05). SNP: Single nucleotide polymorphism; CRC: Colorectal cancer; CON: Control; OR: Odds ratio; CI: Confidence interval; NA: Not available.

Citation: Li YK, Xu Q, Sun LP, Gong YH, Jing JJ, Xing CZ, Yuan Y. Nucleotide excision repair pathway gene polymorphisms are associated with risk and prognosis of colorectal cancer. World J Gastroenterol 2020; 26(3): 307-323
URL: https://www.wjgnet.com/1007-9327/full/v26/i3/307.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i3.307