Clinicopathological characteristics and surgical outcomes of sarcomatoid hepatocellular carcinoma

Table 1 Clinical and laboratory characteristics of the studied patients, n (%)

Variables	Sarcomatoid HCC, n = 41	High-grade HCC, n = 155	P value
Age at diagnosis, median (range), yr	54 (15-74)	55 (28-81)	0.942
Sex (male/female)	33/8	134/21	0.339
Follow-up duration, median (range), mo	10.5 (1.7-81.7)	27.7 (2.1-138.5)	< 0.001
Symptom at diagnosis	32 (78.0)	86 (55.5)	0.009
Alcoholism	10 (24.4)	38 (24.5)	0.987
HBsAg(+)	29 (70.7)	124 (80.0)	0.202
HCV-Ab(+)	3 (7.3)	5 (3.2)	0.368
Liver cirrhosis	32 (78.0)	133 (85.8)	0.226
Child-Pugh class, A/B	36/5	143/12	0.359
AFP, median (range), ng/mL	5.8 (1.0-16660.0)	348.0 (2.0-63208.5)	< 0.001
AFP level			< 0.001
≤ 20 ng/mL	26 (63.4)	33 (21.3)
> 20, < 400 ng/mL	10 (24.4)	47 (30.3)
≥ 400 ng/mL	5 (12.2)	75 (48.4)
Creatinine, median (range), mg/dL	0.77 (0.50-1.11)	0.76 (0.49-1.58)	0.475
ALT, median (range), U/L	26 (10-145)	32 (8-301)	0.204
Total bilirubin, median (range), mg/dL	0.85 (0.33-2.45)	0.95 (0.33-10.29)	0.095
Albumin, mean ± SD, g/dL	3.9 ± 0.5	4.0 ± 0.5	0.082
INR, median (range)	1.11 (0.96-1.53)	1.08 (0.84-1.50)	0.066

AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; HBsAg: Hepatitis B surface antigen; HCC: Hepatocellular carcinoma; HCV-Ab: Hepatitis C virus antibody; INR: International normalized ratio; SD: Standard deviation.