Watch and wait approach in rectal cancer: Current controversies and future directions

Table 1 Time between completion of neoadjuvant therapy and first reassessment in watch and wait clinical studies

Study	Patients (n)	Neoadyuvant therapy		Timing of assessment after CRT
		Radiotherapy schedule	Chemotherapy regimen
Habr-Gama et al[107], 2013	70	54Gy/30	CRT: 5-FU/LV CNCT: 5-FU/LV x3	10 wk
Araujo et al[128], 2015	51	45 Gy/25 or 50, 40 Gy/28	CRT: 5-FU or capecitabine	NS
Smith et al[129], 2012	32	50,4 Gy/28	CRT: 5-FU or capecitabine	4-10 wk
Dalton et al[127], 2012	12	45 Gy/25	CRT: capecitabine	8 wk
Renehan et al[99], 2016	259	45 Gy/25	CRT: 5-FU or capecitabine	≥ 8 wk
Appelt et al[5], 2015	51	60 Gy/30 to tumor + 50 Gy/30 to LNs	Tegafur-uracil (UFT)	6 wk
Vaccaro et al[130], 2016	204	50.4 Gy/28	CRT: 5-FU/LV	8-12 wk
Lai et al[131], 2016	267	45 Gy/25 or 54 Gy/30	CRT: 5-FU/LV	8-12 wk
Martens et al[98], 2016	141	50.4 Gy/28 or 5 Gy/5	CRT: 5-FU	8-20 wk
Creavin et al[132],	362	50-54 Gy/30	CRT: 5-FU	6-8 wk

CRT: Chemoradiation therapy; CNCT: Consolidation chemotherapy; NS: Not stated; 5-FU: 5-fluorouracil; LV: Leucovorin.